Rangle, R. V.
June 1965
Angiology;Jun1965, Vol. 16 Issue 6, p351
Academic Journal
Pargyline hydrochloride was administered to a group of elderly hypertensive patients at an average dose of 72 mg daily for periods of 3 to 21 months. The sitting blood pressure was reduced an average of 44/23 mm Hg. Blood glucose determinations following a glucose tolerance test were performed prior to and following an average of 13 weeks of therapy with pargyline. There was a reduction of blood sugar which averaged 12 mg per cent (per 100 ml). A comparison of blood glucose and blood pressure changes appears to indicate that there is no correlation between the magnitude of the antihypertensive and hypoglycemic response. Symptomatic improvement was experienced by most patients. Side effects were not a problem except in one patient who showed evidence of personality changes and in another patient who had nausea and vomiting. The drug was discontinued in both instances.


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