α-Fetoprotein in Hepatitis Superimposed on Cirrhosis: A Case of Concomitant Hepatitis B Surface Antigen and Antibody Associated with a Major but Transient Increase in the α-Fetoprotein Level

Bergmann, Jean-François; Lang, Françoise; Dechy, Hubert; Dorra, Max
October 1985
American Journal of Gastroenterology;Oct1985, Vol. 80 Issue 10, p810
Academic Journal
A 53-year-old man with hepatitis concurrent with cirrhosis was simultaneusly positive for hepatitis B surface antigen and heterotypic anti HBs antibody. This could be explained by a state of tolerance, with chronic carrying of B virus (subtype a y w3), but would not preclude B virus (subtype d) reinfection, inducing the synthesis of specific anti-d antibodies. In the same patient, the very high level of 3460 ng/ml was reached for α-fetoprotein; this was transitory and returned to normal within 8 months; it was probably due to the acute hepatitis. Thus it appears that, even in cases of cirrhosis, a major rise in this marker does not absolutely imply the presence of hepatocellular carcinoma.


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