TITLE

α-Fetoprotein in Hepatitis Superimposed on Cirrhosis: A Case of Concomitant Hepatitis B Surface Antigen and Antibody Associated with a Major but Transient Increase in the α-Fetoprotein Level

AUTHOR(S)
Bergmann, Jean-François; Lang, Françoise; Dechy, Hubert; Dorra, Max
PUB. DATE
October 1985
SOURCE
American Journal of Gastroenterology;Oct1985, Vol. 80 Issue 10, p810
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A 53-year-old man with hepatitis concurrent with cirrhosis was simultaneusly positive for hepatitis B surface antigen and heterotypic anti HBs antibody. This could be explained by a state of tolerance, with chronic carrying of B virus (subtype a y w3), but would not preclude B virus (subtype d) reinfection, inducing the synthesis of specific anti-d antibodies. In the same patient, the very high level of 3460 ng/ml was reached for α-fetoprotein; this was transitory and returned to normal within 8 months; it was probably due to the acute hepatitis. Thus it appears that, even in cases of cirrhosis, a major rise in this marker does not absolutely imply the presence of hepatocellular carcinoma.
ACCESSION #
16351786

 

Related Articles

  • Cholangiography of Icteric Type Hepatoma. Cheng-Shyong Wu; Shyi-Shane Wu; Pang-Chi Chen; Cheng-Tang Chiu; Shi-Ming Lin; Yi-Yin Jan; Chien-Fu Hung // American Journal of Gastroenterology;May1994, Vol. 89 Issue 5, p774 

    Objectives: Icteric type hepatoma caused by floating tumor debris in the major bile duct was rare. Such cases were often incorrectly identified as biliary carcinoma or choledocholithiasis until pathological proof. The goal of this study was to analyze the cholangiograms of icteric type...

  • SUCCESSFUL ANTIVIRAL THERAPY AND PROGNOSIS IN CIRRHOSIS DUE TO HEPATITIS B. Han, Steven-Huy B.; Martin, Paul // American Journal of Gastroenterology;Jun1998, Vol. 93 Issue 6, p859 

    Comments on several studies on antiviral therapy and prognosis in cirrhosis due to hepatitis B. Annual rate of hepatitis B surface antigen (HBsAg) clearance in a study of HBsAg-positive blood donors; Clinical and histological effects of HBsAg clearance in chronic hepatitis B virus (HBV);...

  • α-Fetoprotein and Its Concanavalin A Affinity in Acute Exacerbation of Chronic Hepatitis B. Sun-Sang Wang; Govindarajan, Sugantha; Shou-Dong Lee; Ashcavai, Mary // American Journal of Gastroenterology;Jan1989, Vol. 84 Issue 1, p46 

    Serum samples from 20 patients with acute exacerbation of chronic hepatitis due to hepatitis B virus and 20 patients with hepatocellular carcinoma arising from B viral cirrhosis with elevated levels of α-fetoprotein (AFP) were analyzed by affinity column chromatography for concanavalin A...

  • FREQUENCY OF HEPATOCELLULAR CARCINOMA IN CIRRHOSIS. Amin, Said; Shabbier, Ghulam; Ul Haq, Anwar; Wazir, Muhammad Noor // Professional Medical Journal;Jan/Feb2012, Vol. 19 Issue 1, p73 

    Objective: To find the frequency of hepatocellular carcinoma in cirrhotic patients of our population. Design: Prospective observational study. Setting: Medical A Unit Hayat Abad Medical Complex Peshawar. Period: 1st January 2010 to 31st July 2011. Material & methods: All patients were screened...

  • Clinical significance of α - fetoprotein in initial diagnosis of primary hepatic cancer. ZHAO Chunhua; ZHOU Wenfeng; CHEN Weihua // Journal of Clinical Hepatology / Linchuang Gandanbing Zazhi;sep2013, Vol. 29 Issue 9, p698 

    Objective To investigate the value of a - fetoprotein (AFP) in the initial diagnosis of primary hepatic cancer (PHC). Meth-ods A retrospective analysis was performed on the initial AFP measurement results and imaging findings of 177 patients who had relatively complete clinical data and had a...

  • Risk factors for naturally-occurring early-onset hepatocellular carcinoma in patients with HBV-associated liver cirrhosis in China. Yuanyuan Li; Zheng Zhang; Jianfei Shi; Lei Jin; Lifeng Wang; Dongping Xu; Fu-Sheng Wang // International Journal of Clinical & Experimental Medicine;2015, Vol. 8 Issue 1, p1205 

    Aims: Early onset of hepatocellular carcinoma (HCC) (males and females under the age of 40 or 50 years old, respectively) has a significant prevalence and poor prognosis; however, few studies have reported the risk factors and development of HCC in such cases. Methods: In this study, we...

  • Anamnestic Response to Hepatitis B Vaccine in Nonalcoholic Liver Cirrhosis Patients with and without HBV-DNA. Baruch, Yaacov; Enat, Rafael; Gershoni-Baruch, Ruth; Rimon, Nurit; Ben-Porath, Edna // American Journal of Gastroenterology;May1992, Vol. 87 Issue 5, p613 

    Two methods were used to unveil a possible previous hepatitis B virus (HBV) infection in patients with post-necrotic liver cirrhosis. The anamnestic response to a booster injection of HB vaccine was assessed, and the polymerase chain reaction (PCR) technique for the detection of HBV-DNA in serum...

  • Clinical and Virological Characteristics Post HBsAg Seroclearance in Hepatitis B Virus Carriers With Hepatic Steatosis Versus Those Without. Chu, Chia-Ming; Lin, Deng-Yn; Liaw, Yun-Fan // Digestive Diseases & Sciences;Jan2013, Vol. 58 Issue 1, p275 

    Background: It has been suggested hepatic steatosis contributes to seroclearance of hepatitis B surface antigen (HBsAg) in chronic hepatitis B virus (HBV) infection. Although HBsAg seroclearance generally confers favorable outcome, hepatic steatosis may account for progressive liver fibrosis and...

  • Long-Term Effect of Interferon Plus Ribavirin on Hepatitis B Surface Antigen Seroclearance in Patients Dually Infected with Hepatitis B and C Viruses. Ming-Lun Yeh; Chao-Hung Hung; Jee-Fu Huang; Chun-Jen Liu; Chuan-Mo Lee; Chia-Yen Dai; Jing-Houng Wang; Zu-Yau Lin; Sheng-Nan Lu; Tsung-Hui Hu; Ming-Lung Yu; Jia-Horng Kao; Wan-Long Chuang; Pei-Jer Chen; Ding-Shinn Chen // PLoS ONE;2011, Vol. 6 Issue 6, p1 

    Background: Interferon-a/ribavirin combination therapy might promote hepatitis B surface antigen (HBsAg) seroclearance in patients dually infected with hepatitis B and C viruses (HBV/HCV), but the long-term effect remains unclear. We aimed to investigate the rate of and the factors associated...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics