Horn, Leif
July 1965
Angiology;Jul1965, Vol. 16 Issue 7, p412
Academic Journal
Local control of smooth muscle responsiveness was investigated employing gastric muscle in vitro. Inhibition of terminal oxidation by cyanide reduced isometric resting tension and produced subsequently a characteristic pattern of periodic contractions with approximately one forceful contraction per minute. Epinephrine abolished the beating. Epinephrine-treated cyanide poisoned muscle resumed beating after application of acetylcholine or other agents normally producing a contraction in this muscle. The work functions elicited by chemical mediators in the presence of cyanide were irregular but they could be normalized by changing the ionic environment of the muscle. The presented data support the concept that the metabolic state of the smooth muscle is influenced by the environmental redox state and this determines the responsiveness.


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