TITLE

THE ARTERIOLAR EFFECTS OF CINNARIZINE AND FLUNARIZINE

AUTHOR(S)
Verhaegen, H.; Roels, V.; Adriaensen, H.; Brugmans, J.; De Cock, W.; Dony, J.; Jageneau, A.; Schuermans, V.
PUB. DATE
April 1974
SOURCE
Angiology;Apr1974, Vol. 25 Issue 4, p261
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Multitechnical non-invasive procedures were used to assess the arteriolar effects of cinnarizine and its difluoroderivative, flunarizine, in 20 normal volunteers and in 43 elderly patients with occlusive disease of the extremities due to arteriosclerosis, 22 of whom had intermittent claudication. The trial involved six separate studies of which three were double-blind cross-over, one was a 6-month open study followed by a 6-month double-blind study and two were open studies. Significant drug-related effects were obtained by venous occlusion plethysmometry, differentiated pulse plethysmometry, oscillometry, claudicometer, postexercise arm-ankle pressure gradients and exercise tolerance measurements, but not by light plethysmometry and skin temperature measurements. The results indicated that cinnarizine and flunarizine improved vascular distension and blood How in normal volunteers, as well as in patients with occlusive disease of the extremities due to arteriosclerosis. The patients also showed increased postexercise arm-ankle pressure gradients, improved arterial pulsations and better exercise performance and tolerance. The drugs were devoid of effects on sympathetic reflexes, resting blood pressure and pulse rate; they were devoid of side-effects and were well tolerated also by patients treated with antihypertensives and cardiac glycosides. Flunarizine was at least as effective as its parent compound at two to three times lower dose levels.
ACCESSION #
16351739

 

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