Sandler, Maurice; Bourne, Geoffry H.
July 1965
Angiology;Jul1965, Vol. 16 Issue 7, p375
Academic Journal
We have attempted to review experimental studies showing a change in the metabolism of the aorta in the rat, human, chimpanzee and dog in the atherosclerotic lesion as well as experimentally in the dog and in the rat prior to the development of the morphologic lesion. The central role of essential fatty acids in the development of this metabolic lesion has been discussed. The importance of this biochemical defect as a marker for the study of an extremely early lesion in the development of atherosclerosis has been stressed. The lack of relationship to cholesterol of this lesion has been emphasized.


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