Menéndez, Carlos; Almonte, J. Corral; Ramos, C. Nuñez
April 1957
Angiology;Apr1957, Vol. 8 Issue 2, p182
Academic Journal
A new drug of the coumarin group has been used in clinical experiments on 50 hospitalized patients in order to determine its advantages over the other anticoagulants. The hypoprothrombinemic section of G-23350 was uniform and steady (this quality was noticed particularly in the chronic stages) and combined with other substances of rapid action (in the acute stages). As soon as the curves are established at the therapeutic level, this drug can be handled with weekly laboratory determinations. To the patient, this means less money spent in laboratory tests and less trouble. Vitamin K1 is the drug of choice to control any bleeding that may appear and it is not necessary to administer a higher dose than that we used. The recommended initial dose for the G-23350 is 32 mg in a single dose. Maintainance doses may vary from 4 to 8 mg.


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