TITLE

UNTOWARD HEMODYNAMIC EFFECTS OF INTRA-ARTERIAL INJECTIONS OF VASODILATOR DRUGS ON THE MUSCLE CIRCULATION IN THE DOG HIND LIMB WITH EXPERIMENTAL ARTERIAL OCCLUSION

AUTHOR(S)
Lambert, J.; Lambert, P. J.
PUB. DATE
July 1967
SOURCE
Angiology;Jul1967, Vol. 18 Issue 7, p415
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Intra-arterial injections of various vasodilator drugs produce, in the muscle circulation of the hind limb of the dog with experimental aorta or femoral artery occlusion, homodynamic changes which counteract a real improvement of the blood supply to the muscle tissues and which must be ascribed to the fact that the collateral vessels are loss dilated than the muscle vascular beds supplied by them. (a) In the resting intrinsic muscle vascular bed distal to the entire collateral network, the arterial pressure gradient is reduced, so that the blood flow is proportionally much less increased than the resistance is decreased; moreover, with the fall of the mean distal arterial pressure under a certain threshold, the distal blood flow is diverted from the nutritive capillary bed to more direct dilated arterio-venous channels. In the case of femoral artery occlusion, untoward effects are added by hemodynamic changes duo to the dilatation of the proximal intrinsic muscle vascular bed which depends only on the proximal part of the collaterals. (b) Because of the same untoward hemodynamic effects, the intra-arterial injection of acetylcholine or histamine proves unable to improve efficaciously the bad conditions of permanent metabolic vasodilatation produced by repeated tetanic contractions in the distal muscle vascular bed, in the case of femoral artery occlusion, when the resting mean distal arterial pressure is low.
ACCESSION #
16351585

 

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