Wyman, Leland C.; Drapeau, Lois L.; Fulton, George P.; Shulman, Maurice H.
April 1957
Angiology;Apr1957, Vol. 8 Issue 2, p170
Academic Journal
1. During four hours of anesthesia induced by Dial with urethane, the arterioles of the cheek pouch reacted in a temporal pattern dominated by moderate vasoconstriction in all control groups (intact, sham-operated, adrenalectomized, adrenalectomized with replacement therapy, intact receiving 12 daily doses of 0.3 mg of cortisone) except for those receiving 5 mg of cortisone daily for 12 days. The venules were not affected significantly. 2. Histamine (30 and 60 mg intraperitoneally) produced arteriolar constriction significantly greater than that of the controls, followed by subsequent dilation in some, and recovery from the effects of the histamine in others. The venules also constricted, recovering later from the smaller dose. 3. Histamine (30 and 60 mg intraperitoneally) produced arteriolar dilation and venular constriction in hamsters pretreated for 12 days with cortisone in 5 mg daily doses. 4. Small amounts of histamine (0.25 mg) produced a pattern of vascular response in adrenalectomized hamsters like that of 30 mg in intact hamsters and mortality like that of 60 mg. Arteriolar constriction occurred, but the venules were relatively unaffected. The vascular reactions were restored to those of the controls by therapy with 1 mg of cortisone daily for 12 days. 5. The susceptibility of blood vessels in the cheek pouch to petechial formation was tested by negative pressure. Significantly fewer petechiae were found in hamsters given 30 or 60 mg of histamine than in the controls. The decrease in susceptibility may be due to the vasoconstrictor effect of the histamine.


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