TITLE

SODIUM AND POTASSIUM DEHYDROCHOLATE AS DIURETIC AGENTS

AUTHOR(S)
Vogl, Alfred; Kaizer, Miltiades
PUB. DATE
April 1957
SOURCE
Angiology;Apr1957, Vol. 8 Issue 2, p145
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. The known potentiating effect of 10 cc of a 20 per cent solution of Decholin Sodium (by intravenous injection) upon mercurial diuresis is confirmed by the studies reported here. Of 19 edematous patients, 11 showed a significant potentiating effect of Decholin Sodium on mercurial diuresis, 6 a fair response and only 2 no response. 2. Acute toxicity studies with 5 to 10 cc of 20 per cent potassium dehydrocholate injected slowly intravenously showed no demonstrable subjective or objective side-effects, in particular no significant electrocardiographic changes. 3. The substitution of potassium dehydrocholate for sodium dehydrocholate did not improve the results. This appears to indicate that the sodium content of Decholin Sodium (120 mg in 10 cc of the 20 per cent solution) does not interfere with the diuretic effectiveness of the bile salt. 4. The oral administration of Decholin in combination with Diamox did not reveal any consistent pattern indicative of a synergistic or potentiating action of these two drugs.
ACCESSION #
16351550

 

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