Jellinek, Harry
September 1967
Angiology;Sep1967, Vol. 18 Issue 9, p547
Academic Journal
In our opinion the fibrinoid necrosis of the small blood vessels is a reaction produced by the noxious effect to which the vascular wall has been exposed, the histologic structure of which is closely correlated with the intensity of the noxa and the duration of exposure. Our experiments have shown that necrosis of the vascular wall develops in sharply distinct phases, which, however, may be not very marked. Their development in time may depend just on the intensity of the etiologic factors, but the histologic pattern which develops this way allows one to draw conclusions, not as to the etiologic factor but only as to the intensity of the noxious effects the blood vessel has been exposed to. These series of experiments also place in a different light the analysis of the fibrinoid necrosis of the vascular wall found in human pathology.


Related Articles

  • Prolonged latency in the baroreflex mediated vascular resistance response in subjects with postural related syncope. Gulli, Giosuè; Cooper, Victoria Louise; Claydon, Victoria Elizabeth; Hainsworth, Roger // Clinical Autonomic Research;Jun2005, Vol. 15 Issue 3, p207 

    In addition to the gain, the delay of the baroreflex response plays an important role in the maintenance of cardiovascular system stability. Additionally when postural changes induce sudden drops in blood pressure, a delayed response may fail to maintain sufficient cerebral perfusion pressure....

  • Thromboxane A2 receptor blockade improves renal function and histopathology in the post-obstructive kidney. Rinder, Craig A.; Halushka, Perry V.; Sens, Mary Ann; Ploth, David W. // Kidney International;Jan1994, Vol. 45 Issue 1, p185 

    To elucidate the role of the vasoconstrictor thromboxane Aâ‚‚(TXAâ‚‚) in post-obstructive nephropathy, we examined the effect of the TXAâ‚‚ receptor antagonist GR32191(GR) on renal function and histopathology in the post-obstructed kidney (POK) in rats. Rats pre-treated with 3 or...

  • Haemodynamic effects of endothelin receptor antagonist, tezosentan, in tumour necrosis factor-α treated anaesthetized rats. Tabrizchi, Reza; Ford, Carol Ann // Naunyn-Schmiedeberg's Archives of Pharmacology;Feb2003, Vol. 367 Issue 2, p156 

    Administration of tumour necrosis factor-α (TNF-α) produces progressive reduction in cardiac output (CO) by affecting preload, afterload and cardiac contractility. We have examined the effect of an endothelin receptor antagonist, tezosentan (1, 3 or 10 mg/kg), on CO, heart rate (HR), blood...

  • The Bradykinin Type 2 Receptor BE1 Polymorphism and Ethnicity Influence Systolic Blood Pressure and Vascular Resistance. Pretorius, M. M.; Gainer, J. V.; Van Guilder, G. P.; Coelho, E. B.; Luther, J. M.; Fong, P.; Rosenbaum, D. D.; Malave, H. A.; Yu, C.; Ritchie, M. D.; Vaughan, D. E.; Brown, N. J. // Clinical Pharmacology & Therapeutics;Jan2008, Vol. 83 Issue 1, p122 

    We examined the effect of −58 C/T and BE1 +9/−9 polymorphisms in the bradykinin B2 receptor gene on forearm vascular resistance (FVR) before and during intrabrachial artery infusion of the B2 receptor-, endothelium-dependent agonist bradykinin and the endothelium-independent agonist...

  • Nitric oxide modulates renal vasoconstrictor effect of endothelin-1 in conscious lambs. Smith, Francine G.; van der Velde, Liesbeth; Sener, Alp // Pediatric Nephrology;Nov2005, Vol. 20 Issue 11, p1545 

    To test the hypothesis that nitric oxide (NO) buffers the renal vasoconstrictor effects of endothelin-1 (ET-1) early in life, renal haemodynamic responses to ET-1 were measured in the presence and absence of endogenously produced NO in conscious lambs. Renal haemodynamic effects of ET-1 were...

  • 352 The impact of cardiac resynchronisation therapy on systemic vascular resistance. Patwala, A.Y.; Woods, P.; Barker, D.; Williams, S.G.; Goldspink, D.F.; Tan, L.B.; Wright, D.J. // European Journal of Heart Failure. Supplements;Jun2006, Vol. 5 Issue 1, p75 

    An abstract of the study "The impact of cardiac resynchronisation therapy on systemic vascular resistance," by A. Y. Patwala and colleagues, is presented.

  • Hypertension and microvascular remodelling. Feihl, François; Liaudet, Lucas; Levy, Bernard I.; Waeber, Bernard // Cardiovascular Research;May2008, Vol. 78 Issue 2, p274 

    In the present review, microvascular remodelling refers to alterations in the structure of resistance vessels contributing to elevated systemic vascular resistance in hypertension. We start with some historical aspects, underscoring the importance of Folkow’s contribution made half a...

  • Does size matter? Larger Blalock–Taussig shunt in the modified Norwood operation correlates with better hemodynamics Photiadis, Joachim; Hübler, Michael; Sinzobahamvya, Nicodème; Ovroutski, Stanislav; Stiller, Brigitte; Hetzer, Roland; Urban, Andreas E.; Asfour, Boulos // European Journal of Cardio-Thoracic Surgery;Jul2005, Vol. 28 Issue 1, p56 

    Abstract: Objective: Excess pulmonary to systemic blood flow ratio (Qp/Qs) correlates with hemodynamic instability and mortality after modified Norwood operation. Studies suggest that maximal oxygen delivery occurs at a Qp/Qs of around 1. The use of a rather small modified Blalock–Taussig...

  • Mild Renal Dysfunction and Renal Vascular Resistance in Primary Hypertension Derchi, Lorenzo E.; Leoncini, Giovanna; Parodi, Denise; Viazzi, Francesca; Martinoli, Carlo; Ratto, Elena; Vettoretti, Simone; Vaccaro, Valentina; Falqui, Valeria; Tomolillo, Cinzia; Deferrari, Giacomo; Pontremoli, Roberto // American Journal of Hypertension;Jul2005, Vol. 18 Issue 7, p966 

    Background: Mild renal dysfunction (MRD) is an often overlooked but relatively common condition in patients with primary hypertension (PH), and is associated with high cardiovascular morbidity and mortality. Whether MRD is also associated with abnormalities in renal vascular resistance is...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics