TITLE

VARIATIONS IN CAPACITY OF RABBITS TO HANDLE INGESTED CHOLESTEROL

AUTHOR(S)
Collens, William S.
PUB. DATE
December 1957
SOURCE
Angiology;Dec1957, Vol. 8 Issue 6, p513
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The addition of cholesterol to the daily diet of 100 rabbits revealed individual variations in the capacity of these animals to handle the ingested cholesterol. Although some showed a brisk hypercholesterolemic response to feeding 1 gm of cholesterol per day, others showed no response until 5 gm were added to the daily ration. Where a hypercholesterolemic response followed the daily ingestion of cholosterol, observation of the serum levels followed weekly while the feedings were continued, and showed a subsequent subsidence in the hypercholesterolemia, only to rise again on increasing the dose of the cholesterol feeding. It is suspected that there is a homeostatic mechanism operating in the organism which regulates the metabolism of cholesterol in these animals and controls its concentration in the blood. The implications in human atherosclerotic disease of these variations in the rabbit are discussed.
ACCESSION #
16351380

 

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