Garnes, Arthur L.; Barnard, Robert D.
February 1957
Angiology;Feb1957, Vol. 8 Issue 1, p13
Academic Journal
Histologic studies of chronic dermal ulcers which had proved unresponsive to local antibacterial therapy and to treatment of vascular or other systemic deficiencies indicate the majority to be incapable of healing because of capillary blockage accompanied by collagenization of fibrous tissues, The causative factor of capillary blockage is identified as erythrocyte agglutination by the products of tissue breakdown (mucopolysaccharides, nucleoproteins). The hypothesis is advanced that successful treatment of these static ulcers requires a proteolytic agent capable of removing the collagen barrier and a hemagglutination inhibitor to combat capillary blockage. A clinical series is described in which topical treatment with a combination of an antiagglutinin, cuprichlorophyllinate, and a proteolytic agent, papain-urea, in ointment vehicle, produced complete healing of 80 per cent of selected dermal ulcers resistant to previous theraphy. These results wore significantly superior to those obtained in similar cases with the proteolytic agent alone or with an antiagglutinin alone. Special note is made of the unusual quality of healing and of the fact that all cases which showed any response to the antiagglutinin-proteolytic therapy progressed promptly to complete healing.


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