Datey, K. K.; Pandya, V. N.
April 1965
Angiology;Apr1965, Vol. 16 Issue 4, p155
Academic Journal
1. Alpha methyl dopa was tried on 39 hypertensive patients. 2. Methyldopa is a decarboxylase inhibitor. However, its exact mode of hypertensive action is not clear. 3. It acts in about 3 to 4 hr., and the duration of its action is about 6 to 8 hr. The maximal effect occurs 24 to 48 hr. after instituting therapy. 4. When hypertension is mild to moderate in degree, the pressure is lowered mainly in the supine position, without much postural hypotension. 5. When hypertension is severe, the pressure is usually lowered in the upright position. However, in about one-third of the cases there is a significant fall in the sitting posture which is a distinct advantage. 6. The effect of exercise in the patients on treatment is discussed. 7. The side effects are not troublesome. An unusual one, constipation, occurred in this series. 8. Tolerance is sometimes rapidly established. 9. Though far from ideal, methyldopa is a welcome addition to the existing antihypertensive drugs. It has a few side effects ad is particularly useful in moderate hypertension.


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