TITLE

THE EFFECTS OF AZAPETINE INFUSIONS ON PATIENTS WITH VASCULAR DISEASE

AUTHOR(S)
Jeffords, J. Vernon; Stallworth, J. Manly
PUB. DATE
October 1956
SOURCE
Angiology;Oct1956, Vol. 7 Issue 5, p445
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
1. No change was noted in the degree of intravascular agglutination following intravenously administered azapetine. 2. In every case studied the bulbar conjunctival vessels became dilated, resulting in an increase in vascularity and blood flow following use of azapetine. 3. The response to intravenous azapetine was proportional to the degree of vasospasm present as determined by clinical methods. 4. The intravenous dosage of azapetine for use in acute vasospasm varies from 0.2 to 0.8 mg/kg in 250 cc saline. 5. The side effects are more frequent and severe in intravenous azapetine than in the oral form of the drug. 6. Every patient studied with arteriosclerosis obliterans and acute vasospastic disease presented a moderate to marked degree of “sludging” and intravascular abnormalities as seen in the bulbar conjunctival vessels. 7. The effects of azapetine on the conjunctival vessels appears to correlate closely with the effect on blood flow in the digits and as such offers a readily accessible system of vessels for direct study hi the use of vaso-reactive drugs.
ACCESSION #
16350373

 

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