Seegers, Walter H.
October 1956
Angiology;Oct1956, Vol. 7 Issue 5, p436
Academic Journal
Purified prothrombin can be isolated from plasma and is a complex glyco-protein that alone possesses the materials needed to obtain thrombin. Prothrombin can also be converted to other derivatives and these are concerned with the conversion of prothrombin to thrombin. One of the prothrombin derivatives functions with thromboplastin and another with platelet factor 3 in the conversion of prothrombin to thrombin. With oral anticoagulants, the plasma concentration of prothrombin and also that of the derivatives diminishes.


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