Bellman, Sven; Adams-Ray, Jack
August 1956
Angiology;Aug1956, Vol. 7 Issue 4, p339
Academic Journal
Cold injuries have been produced in rabbit ears using a standard and the effects of rapid and �slow� thawing of the tissue have been studied by meastiring the extent of the resulting tissue defect. The effect of the cold trauma on the vascular system has been studied by microangiography. It was shown that cold trauma involving rapid freezing maintaining at a constant, low temperature for ten minutes and then rapid thawing, injured the tissue less than a similar cold trauma involving slow thawing. The following vascular reactions were demonstrated: In the early period, studied between 2.17 and 21.20 minutes after the cold trauma: frequent strong artery spasms, localized almost exclusively in the border zone between frozen and nonfrozen tissue. Occasional slight venous spasms, which were not confined to any particular area of the cold injury. A great number of open arterio-venous shunts both in the cold injury and in the rest of the ear. Exclusion of the smallest blood vessels from the blood circulation: this was observed about 7 minutes after thawing, but in many cases it was found in the earliest microangiograms that could be taken. This stasis was seen up to 8 days after the cold trauma, even when slight or no subsequent necrosis of the tissue was produced. Later after the cold trauma: 1 to 2 days after the cold trauma there appeared a great number of small blood vessels which, within few days, developed a system of tortuous arteries and veins with diameters up to 0.3 mm. Within the time investigated this ingrowth of blood vessels did not cover more than the outer part of the cold injury. A total reconstruction of the system of small and middle-sized blood vessels was eventually demonstrated. No differences were found in the type or extent of vascular reactions between rapidly and �slowly� thawed cold injuries. No certain difference in vascular reactions was found between cold injuries which developed necrosis and those which did not.


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