TITLE

ENDOCRINE MANIPULATIONS AND EXPERIMENTAL INTIMAL LESIONS

AUTHOR(S)
Groover Jr., M. E.
PUB. DATE
March 1965
SOURCE
Angiology;Mar1965, Vol. 16 Issue 3, p106
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Attempts to explore some of the mechanism that may be responsible for the sex difference in death rate for atherosclerotic heart disease has revealed a slight tendency for estradiol to produce slight intimal thickening but no recognizable lesions in 1-year-old rats, and in young castrated male baboons. Testosterone increases the hematocrit and increases the size of experimental intravascular clots. This effect is reversed if the animals' hematocrit is kept at the pretreatment level, suggesting that the increased hematocrit may be the mechanism whereby experimental intra-arterial lesions are larger in males. The possibility of other colloidal changes in blood has been discussed.
ACCESSION #
16349027

 

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