TITLE

The polymorphism interleukin 8 - 251 A/T influences the susceptibility of Helicobacter pylori related gastric diseases in the Japanese population

AUTHOR(S)
Ohyauchi, M.; Imatani, A.; Yonechi, M.; Asano, N.; Miura, A.; Lijima, K.; Koike, I.; Sekine, H.; Ohara, S.; Shimosegawa, I.
PUB. DATE
March 2005
SOURCE
Gut;Mar2005, Vol. 54 Issue 3, p330
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Helicobacter pylon infection is associated with variable clinical outcomes, including gastroduodenal diseases, and genetic factors may be relevant in this process. Aims: We investigated the effects of an interleukin 8 (11-8) gene polymorphism on the risk of gastroduodenal diseases, the degree of H pylon induced gastritis, and IL-8 gene transcription. Subjects: The study was performed in 244 healthy control subjects and 690 H pylon positive patients with non-cardia gastric cancer, gastric ulcer, duodenal ulcer, or gastritis. Methods: We identified the 1L-8 -251 A/T polymorphism by direct sequence analysis, and measured the gastritis score and serum pepsinogen (PG). The transcriptional promoter activity of the IL-8 gene was assessed by luciferase assay. Results: IL-8 -251 A was associated with a higher risk of gastric cancer and gastric ulcer. Patients carrying IL-8 -251A showed an increased risk of gastric cancer (odds ratios (OR) 2.01 (95% confidence interval (CI) 1.38-2.92)) and gastric ulcer (OR 2.07(95% CI 1.37-3.12)). Compared with patients younger than 49 years, atrophy and metaplasia scores in the antrum were significantly higher and the PG I/II ratio significantly lower in -251A carriers than in T/T carriers. In the in vitro assay, IL-B -251 A showed enhanced promoter activity in response to IL-1β or tumour necrosis factor α. Conclusions: The IL-8 -251A allele may be associated with progression of gastric atrophy in patients with H pylon infection, and may increase the risk of gastric cancer and gastric ulcer in Japanese people.
ACCESSION #
16348856

 

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