Microbes, immunoregulation, and the gut

Rook, G. A. W.; Brunet, I. R.
March 2005
Gut;Mar2005, Vol. 54 Issue 3, p317
Academic Journal
Two distinct, but rapidly converging, areas of research (the hygiene hypothesis and the study of probiotic/prebiotic effects) have emphasised the need to understand, and ultimately to manipulate, our physiological interactions with commensal flora, and with other transient but harmless organisms from the environment that affect immunoregulatory circuits. The story began with allergic disorders but now inflammatory bowel disease is increasingly involved.


Related Articles

  • Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Kugathasan, S.; Saubermann, L. J.; Smith, L.; Kou, D.; Itoh, J.; Binion, D. C.; Levine, A. D.; Blumberg, R. S.; Fiocchi, C. // Gut;Dec2007, Vol. 56 Issue 12, p1696 

    Background and aims: Crohn's disease is a life-long form of inflammatory bowel disease (IBD) mediated by mucosal immune abnormalities. Understanding of the pathogenesis is limited because it is based on data from adults with chronic Crohn's disease. We investigated mucosal T-cell...

  • Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function. Braat, Henri; de Jong, Esther C.; van den Brande, Jan M. H.; Kapsenberg, Martien L.; Peppelenbosch, Maikel P.; van Tol, Eric A. F.; van Deventer, Sander J. H. // Journal of Molecular Medicine;Mar2004, Vol. 82 Issue 3, p197 

    The reaction of the intestinal immune system to intestinal bacteria shows striking differences between various bacterial strains. Whereas Klebsiella pneumoniae induces a fierce proinflammatory reaction, the probiotic strain Lactobacillus rhamnosus has clear anti-inflammatory effect in...

  • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Bouskra, Djahida; Brézillon, Christophe; Bérard, Marion; Werts, Catherine; Varona, Rosa; Boneca, Ivo Gomperts; Eberl, Gérard // Nature;11/27/2008, Vol. 456 Issue 7221, p507 

    Intestinal homeostasis is critical for efficient energy extraction from food and protection from pathogens. Its disruption can lead to an array of severe illnesses with major impacts on public health, such as inflammatory bowel disease characterized by self-destructive intestinal immunity....

  • Regulatory mechanisms of immune responses to intestinal bacteria. Honda, K.; Takeda, K. // Mucosal Immunology (1933-0219);May2009, Vol. 2 Issue 3, p187 

    The intestinal mucosa allows the residence of trillions of bacteria with which it interacts dynamically. To establish and maintain a mutually beneficial relationship, the mucosal immune system must enforce tolerance toward the vast non-pathogenic microbiota while simultaneously remaining...

  • The ATG16L1 Gene Variants rs2241879 and rs2241880 (T300A) Are Strongly Associated With Susceptibility to Crohn's Disease in the German Population. Glas, Jürgen; Konrad, Astrid; Schmechel, Silke; Dambacher, Julia; Seiderer, Julia; Schroff, Frieder; Wetzke, Martin; Roeske, Darina; Török, Helga-Paula; Tonenchi, Laurian; Pfennig, Simone; Haller, Dirk; Griga, Thomas; Klein, Wolfram; Epplen, Jörg T.; Folwaczny, Christian; Lohse, Peter; Göke, Burkhard; Ochsenkühn, Thomas; Mussack, Thomas // American Journal of Gastroenterology;Mar2008, Vol. 103 Issue 3, p682 

    OBJECTIVES: We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene expression. METHODS: Genomic DNA from 2,890...

  • Inhibition of Histone Deacetylases in Inflammatory Bowel Diseases. Glauben, Rainer; Siegmund, Britta // Molecular Medicine;May/Jun2011, Vol. 17 Issue 5/6, p426 

    This review, comprised of our own data and that of others, provides a summary overview of histone deacetylase (HDAC) inhibition on intestinal inflammation as well as inflammation-mediated carcinogenesis. Experimental colitis in mice represents an excellent in vivo model to define the specific...

  • Suppressor of cytokine signalling 1 in lymphocytes regulates the development of intestinal inflammation in mice. K. Inagaki-Ohara; A. Sasaki; G. Matsuzaki; I. Ikeda; M. Hotokezaka; K. Chijiiwa; M. Kubo; H. Yoshida; Y. Nawa; A. Yoshimura // Gut;Feb2006, Vol. 55 Issue 2, p212 

    Background and aims: Imbalance between pro- and anti-inflammatory cytokines produced by intestinal T cells induces inflammatory bowel diseases (IBD). However, the importance of regulation of cytokine signalling in IBD has not been fully clarified. We have demonstrated that suppressor of cytokine...

  • Immunoregulatory cytokines and intestinal inflammation. Mitsuyama, Keiichi; Toyonaga, Atsushi; Sata, Michio // Journal of Gastroenterology;Feb2005, Vol. 40 Issue 2, p217 

    The article focuses on the expression of immunoregulatory cytokines in inflammatory bowel disease (IBD). There is strong evidence that the abnormal expression and responses of immunoregulatory cytokines, including interleukin (IL)-2, IL-7, and IL-15, are involved in IBD pathogenesis. IL-2 is a...

  • Dysbiosis in inflammatory bowel disease. Tamboli C P; Neut C; Desreumaux P; Colombel J F // Gut;Jan2004, Vol. 53 Issue 1, p1 

    Abundant data have incriminated intestinal bacteria in the initiation and amplification stages of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains elusive. One theory has suggested a breakdown in the balance between putative species of "protective" versus...


Read the Article


Sign out of this library

Other Topics