TITLE

Barrett's oesophagus: the new endoscopic modalities have a future

AUTHOR(S)
Deviere, J.
PUB. DATE
March 2005
SOURCE
Gut;Mar2005 Supplement 1, Vol. 54, pi33
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Barrett's oesophagus is defined as the replacement of squamous oesophageal epithelium by intestinal metaplasia in the distal oesophagus. It is a fairly frequent complication of gastro-oesophageal reflux disease (GORD): 5-10% of patients with GORD suffer from Barrett's oesophagus. GORD is essential for the development of Barren's oesophagus. Intestinal metaplasia is a premalignant lesion that may further develop into dysplasia and lead to adenocarcinoma of the oesophagus. The latter now accounts for almost 50% of oesophageal cancer cases in western countries, and the largest increase in its incidence was recorded during the past two decades. Patients with Barren's oesophagus have a 2-25% risk of developing mild to severe dysplasia and a 2-5% risk of having adenocarcinoma: 30-150 times higher than the risk in the general population. Forty to fifty per cent of Barren's oesophagus patients with severe dysplasia would present adenocarcinoma within 5 years.
ACCESSION #
16348820

 

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