TITLE

Are screening and surveillance for Barrett's oesophagus really worthwhile?

AUTHOR(S)
Sharma, P.; Sidorenko, E. I.
PUB. DATE
March 2005
SOURCE
Gut;Mar2005 Supplement 1, Vol. 54, pi27
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Oesophageal adenocarcinoma has a low incidence and still remains an uncommon cancer; however, it has been on the rise over the past 20 years. Barrett's oesophagus, a complication of gastro-oesophageal reflux disease, is the only known precursor of this adenocarcinoma. It can often be asymptomatic and probably goes undiagnosed in the majority of the population. There are no direct data supporting the practice of screening for Barrett's oesophagus and oesophageal adenocarcinoma among the general population or even in patients with chronic reflux symptoms. However, many argue that the detection of neoplasms at a curable state in a high risk population can perhaps justify screening endoscopy. No prospective, controlled trials have been conducted to support the effectiveness of surveillance, but some indirect evidence does exist. The cost effectiveness of surveillance programmes needs to be further assessed in prospective studies. Ultimately, the use of better tools to diagnose Barrett's oesophagus and dysplasia and the identification of high risk groups for progression to oesophageal adenocarcinoma could potentially make screening and surveillance a cost effective practice.
ACCESSION #
16348819

 

Related Articles

  • Surveillance in Barrett's esophagus: an audit of practice. Ajumobi, Adewale; Bahjri, Khaled; Jackson, Christian; Griffin, Ronald // Digestive Diseases & Sciences;Jun2010, Vol. 55 Issue 6, p1615 

    Goals: Determine the rates of follow-up, incident rate of cancer during surveillance, and changes in pathologic grade of patients with Barrett's esophagus during surveillance in a gastroenterology practice without a formal surveillance program.Background: Barrett's...

  • The Cost of Surveillance for Adenocarcinoma Complicating Barrett's Esophagus. Achkar, Edgar; Carey, William // American Journal of Gastroenterology;Mar1988, Vol. 83 Issue 3, p291 

    A review of endoscopic records at the Cleveland Clinic Foundation over a 7-yr period yielded 72 cases of Barrett's esophagus. Ten patients had adenocarcinoma at the time of diagnosis of Barrett's esophagus (14%). Sixty-two were followed for a mean of 31 months (range 2-154 months). During this...

  • The Incidence of Adenocarcinoma in Barrett's Esophagus: A Prospective Study of 170 Patients Followed 4.8 Years. Drewitz, D. J.; Sampliner, R. E.; Garewal, H. S. // American Journal of Gastroenterology;Feb1997, Vol. 92 Issue 2, p212 

    Objectives: Barrett's esophagus is a premalignant condition defined by the presence of intestinal metaplasia in the esophagus. Estimates of the incidence of adenocarcinoma developing in patients with Barrett's esophagus vary widely. We prospectively followed a cohort of patients to define the...

  • Short Segment Barrett's Esophagus: Clinical and Histological Features, Associated Endoscopic Findings, and Association with Gastric Intestinal Metaplasia. Weston, Allan P.; Krmpotich, Philip; Makdisi, Walid F.; Cherian, Rachel; Dixon, Anita; McGregor, Douglas H.; Banerjee, Sushanta K. // American Journal of Gastroenterology;May1996, Vol. 91 Issue 5, p981 

    Objectives: To prospectively determine the clinical features, associated esophageal endoscopic lesions, associated gastric intestinal metaplasia, and prevalence of dysplasia and adenocarcinoma of short segment Barrett's. Methods: All patients undergoing upper endoscopy over a 5-month period were...

  • Systematic Four-Quadrant Biopsy Detects Barrett's Dysplasia in More Patients Than Nonsystematic Biopsy. Abela, Jo-Etienne; Going, James J.; Mackenzie, John F.; McKernan, Margaret; O'Mahoney, Sylvia; Stuart, Robert C. // American Journal of Gastroenterology;Apr2008, Vol. 103 Issue 4, p850 

    AIMS: To compare detection of Barrett's dysplasia and adenocarcinoma by systematic versus nonsystematic surveillance biopsy protocols. METHODS: Upper GI consultation and open-access endoscopy are provided jointly at Glasgow Royal Infirmary by medical and surgical teams. The surgical team adopted...

  • The Role of Overdiagnosis and Reclassification in the Marked Increase of Esophageal Adenocarcinoma Incidence. Pohl, Heiko; Welch, H. Gilbert // JNCI: Journal of the National Cancer Institute;1/19/2005, Vol. 97 Issue 2, p142 

    Background: The incidence of esophageal adenocarcinoma is rising dramatically. This increase may reflect increased disease burden, reclassification of related cancers, or overdiagnosis resulting from increased diagnostic intensity, particularly upper endoscopy for patients with gastroesophageal...

  • BARRETT'S OESOPHAGUS: AND AUDIT OF SURVEILLANCE OVER A 15 YEAR PERIOD. Gladman, L.; Chapman, W.; Iqbal, T. H.; Cooper, B. T. // Gut;Apr2004 Supplement 3, Vol. 53, pA54 

    Published reports of endoscopic surveillance of patients with Barrett's oesophagus (BO) have concentrated on the development of dysplasia and adenocarcinoma. No studies have audited what happens to patients with BO with regard to entry into or continuation with endoscopic surveillance...

  • Changing Trends in Esophageal Cancer: A 15-Year Experience in a Single Center. Sharma, Virender K.; Chockalingam, Hema; Hornung, Carlton A.; Vasudeva, Rajeev; Howden, Colin W. // American Journal of Gastroenterology;May1998, Vol. 93 Issue 5, p702 

    Objective: Esophageal adenocarcinoma is increasing in white men. We sought to identify trends in esophageal cancer in different patient groups in our region. Methods: We reviewed the records of all patients with esophageal cancer seen at two hospitals in Columbia, SC between 1981 and 1995....

  • Is a single-item visual analogue scale as valid, reliable and responsive as multi-item scales in measuring quality of life? de Boer, A. G. E. M.; van Lanschot, J. J. B.; Stalmeier, P. F. M.; van Sandick, J. W.; Hulscher, J. B. F.; de Haes, J. C. J. M.; Sprangers, M. A. G. // Quality of Life Research;Mar2004, Vol. 13 Issue 2, p311 

    Purpose: To compare the validity, reliability and responsiveness of a single, global quality of life question to multi-item scales.Method: Data were obtained from 83 consecutive patients with oesophageal adenocarcinoma undergoing either transhiatal or transthoracic...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics