Adenocarcinoma of oesophaqus: what exactly is the size of the problem and who is at risk?

Lagergren, J.
March 2005
Gut;Mar2005 Supplement 1, Vol. 54, pi1
Academic Journal
The incidence of oesophageal adenocarcinoma is increasing and the prognosis is poor. There is a strong predominance of white males, and heredity plays a minor role. The established risk factors are Barrett's oesophagus, gastro-oesophageal reflux, and obesity. infection with Helicobacter pylori and use of non-steroidal anti- inflammatory drugs might reduce the risk. Medications that relax the lower oesophageal sphincter might contribute to increasing the risk. Among dietary factors, low intake of fruit, vegetables, and cereal fibres seem to increase the risk of oesophageal adenocarcinoma. The role of tobacco smoking is probably limited and alcohol consumption is not a risk factor. It is uncertain which factors cause the increasing incidence. increasing prevalences of reflux and obesity, and decreasing prevalence of H pylon infection may contribute to this development; however, the sex distributions of these factors do not match the incidence trends well: Endoscopic surveillance for oesophageal adenocarcinoma among persons with reflux and obesity is discussed, but presently there is no evidence that strongly supports such a strategy.


Related Articles

  • Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma. Kawakami, Kazuyuki; Brabender, Jan; Kawakami, K; Brabender, J; Lord, R V; Groshen, S; Greenwald, B D; Krasna, M J; Yin, J; Fleisher, A S; Abraham, J M; Beer, D G; Sidransky, D; Huss, H T; Demeester, T R; Eads, C; Laird, P W; Ilson, D H; Kelsen, D P; Harpole, D // JNCI: Journal of the National Cancer Institute;11/15/2000, Vol. 92 Issue 22, p1805 

    Background: The adenomatous polyposis coli (APC) locus on chromosome 5q21-22 shows frequent loss of heterozygosity (LOH) in esophageal carcinomas. However, the prevalence of truncating mutations in the APC gene in esophageal carcinomas is low. Because hypermethylation of promoter...

  • Obesity might increase risk for esophageal adenocarcinoma. Burress, Paul // Endocrine Today;1/10/2008, Vol. 6 Issue 1, p35 

    This article discusses research being done on combined effects of obesity, acid reflux and smoking on the risk of adenocarcinomas of the esophagus. It references a study by D. C. Whiteman et al., published in a 2007 issue of the journal "Gut." The researchers measured risk levels of...

  • LC3B globular structures correlate with survival in esophageal adenocarcinoma. El-Mashed, Shereen; O'Donovan, Tracey R.; Kay, Elaine W.; Abdallah, Ayat R.; Cathcart, Mary-Clare; O'Sullivan, Jacintha; O'Grady, Anthony; Reynolds, John; O'Reilly, Seamus; O'Sullivan, Gerald C.; McKenna, Sharon L. // BMC Cancer;Aug2015, Vol. 15 Issue 1, p1 

    Background: Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25%. Only a limited number of patients benefit from chemotherapy and there are no biomarkers that can predict...

  • Comparison of cyclooxygenase 2 expression in adenocarcinomas of the gastric cardia and distal oesophagus. Buskens, C. J.; Sivula, A.; van Rees, B. P.; Haglund, C.; Offerhaus, G. J. A.; van Lanschot, J. J. B.; Ristimäki, A. // Gut;Dec2003, Vol. 52 Issue 12, p1678 

    Background: Adenocarcinomas of the gastric cardia and distal oesophagus are at present often considered as one clinical entity because of their comparable increasing incidence, prognosis, and optimal treatment options. However, it is still a mailer of debate whether these malignancies have the...

  • The significance of the HER-2 status in esophageal adenocarcinoma for survival: an immunohistochemical and an in situ hybridization study†. Prins, M. J. D.; Ruurda, J. P.; van Diest, P. J.; van Hillegersberg, R.; ten Kate, F. J. W. // Annals of Oncology;May2013, Vol. 24 Issue 5, p1290 

    Background In esophageal adenocarcinoma (EAC), concordance and prognostic significance of human epidermal growth factor 2 (HER-2) protein overexpression and gene amplification are equivocal, which led us to reevaluate this by immunohistochemistry (IHC) and in situ hybridization. Methods One...

  • SATB1 is an independent prognostic factor in radically resected upper gastrointestinal tract adenocarcinoma. Hedner, Charlotta; Gaber, Alexander; Korkocic, Dejan; Nodin, Björn; Uhlén, Mathias; Kuteeva, Eugenia; Johannesson, Henrik; Jirström, Karin; Eberhard, Jakob // Virchows Archiv;Dec2014, Vol. 465 Issue 6, p649 

    Gastric cancer is the second most common cause of cancer-related death worldwide, and the incidence of esophageal adenocarcinoma is rising. While some progress has been made in treatment strategies, overall survival remains very poor for patients with adenocarcinoma in the upper gastrointestinal...

  • Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON). Cook, Michael B.; Corley, Douglas A.; Murray, Liam J.; Liao, Linda M.; Kamangar, Farin; Ye, Weimin; Gammon, Marilie D.; Risch, Harvey A.; Casson, Alan G.; Freedman, Neal D.; Chow, Wong-Ho; Wu, Anna H.; Bernstein, Leslie; Nyrén, Olof; Pandeya, Nirmala; Whiteman, David C.; Vaughan, Thomas L. // PLoS ONE;Jul2014, Vol. 9 Issue 7, p1 

    Background: Previous studies have evidenced an association between gastroesophageal reflux and esophageal adenocarcinoma (EA). It is unknown to what extent these associations vary by population, age, sex, body mass index, and cigarette smoking, or whether duration and frequency of symptoms...

  • Neoadjuvant Radiochemotherapy in Adenocarcinoma of the Esophagus: ERCC1 Gene Polymorphisms for Prediction of Response and Prognosis. Metzger, Ralf; Warnecke-Eberz, Ute; Alakus, Hakan; Kütting, Fabian; Brabender, Jan; Vallböhmer, Daniel; Grimminger, Peter; Mönig, Stefan; Drebber, Uta; Hölscher, Arnulf; Bollschweiler, Elfriede // Journal of Gastrointestinal Surgery;Jan2012, Vol. 16 Issue 1, p26 

    Introduction: Neoadjuvant radiochemotherapy (RT/CTx) regimens were primarily designed for treatment of squamous cell carcinoma of the esophagus. Own preliminary results demonstrate that also patients with locally advanced adenocarcinoma of the esophagus may achieve a major response in 30% with a...

  • Matrix metalloproteinase 1, 3 and 12 polymorphisms and esophageal adenocarcinoma risk and prognosis. Bradbury, Penelope A.; Zhai, Rihong; Hopkins, Jessica; Kulke, Matthew H.; Heist, Rebecca S.; Singh, Simron; Zhou, Wei; Ma, Clement; Xu, Wei; Asomaning, Kofi; Ter-Minassian, Monica; Wang, Zhaoxi; Su, Li; Christiani, David C.; Liu, Geoffrey // Carcinogenesis;May2009, Vol. 30 Issue 5, p793 

    The matrix metalloproteinase (MMP) family degrade extracellular matrix and mediate pathways including apoptosis, angiogenesis and immunity. We studied the association between four MMP polymorphisms within three MMP genes and esophageal adenocarcinoma (EA) risk and prognosis. A total of 313 EA...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics