No Metabolic Side Effects of Long--Term Treatment with Verapamil in Hypertension

Midtbø, Kjell; Lauve, Oddveig; Hals, Ottar
December 1988
Angiology;Dec1988, Vol. 39 Issue 12, p1025
Academic Journal
In a prospective, open study 45 patients (mean age fifty-three years) with essential hypertension were treated with verapamil for four to eight years (mean 5.3 years). Blood pressure was satisfactorily controlled (from 160/104 to 145/91) and the side effects were infrequent, mild, and often transient. Verapamil did not exert any unfavorable metabolic or hematologic effects over the years. HDL-cholesterol was moderately increased (mean 24%) and the other plasma lipids were unaffected. These data suggest that the calcium channel blocker verapamil is a metabolically safe drug to use as monotherapy in essential hypertension.


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