Leishman, A. W. D.; Oxon, D. M.; Sandler, G.
November 1967
Angiology;Nov1967, Vol. 18 Issue 11, p705
Academic Journal
The progress of 224 hypertensive patients (112 male; 112 female) treated with guanethidine for 1 to 5½ years is reported. The daily dose of guanethidine has varied from 10 to 200 mg. Fewer than half the patients have required a diuretic drug in addition. One third of the patients required a progressively increased dose of guane- thidine for maintenance of blood pressure control, but true tolerance was encountered in only seven cases. Over the whole period of observation an average of 83 per cent of patients showed at least moderate blood pressure control, while over 60 per cent had excellent or good control. Side-effects were not troublesome and diarrhea was readily controlled by codeine phosphate. Seventeen patients died; in 12 of these the blood pressure was poorly controlled. This mortality rate is appreciably lower than was found when comparable groups of hypertensive patients were treated by ganglion-blocking drugs. Treatment with guanethidine has not appeared to increase the hazard of myocardial or cerebral ischemia, but a slowly rising blood urea has been a prominent feature among patients so treated.


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