TITLE

COMPARATIVE EFFECTS OF DIHYDROERGOTAMINE AND HYDERGIN� ON THE BLOOD FLOW, CAPILLARY FILTRATION RATE AND THE CAPACITANCE VESSELS IN THE HUMAN CALF STUDIED BY PLETHYSMOGRAPHY

AUTHOR(S)
Ulrich, Jorgen; Jessen, B.; Siggaard-Andersen, J.
PUB. DATE
December 1973
SOURCE
Angiology;Dec1973, Vol. 24 Issue 11, p657
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Acute experiments concerning the effect of dihydroergotamine, Hydergin and placebo (saline) on the blood flow and the capillary, filtration and the capacitance vessels of the calf, as well as the blood pressure of the distal thigh were studied in normal adults by aid of plethysmography. Hydergin increased significantly the mean value of the resting blood flow with 43 per cent (P < 0.001) while dihydroergotamine did not influence the blood flow significantly. Hydergin produced a decrease of the capillary filtration rate with about 22 per cent possibly due to a decreased blood pressure in the thigh q P < 0.05). No significant effect of dihydroergotamine was found on the capillary filtration rate or on the distal blood pressure in the thigh. On the venous side no effect was observed after Hydergin. Dihydroergotamine provoked strong constrictor response of the capacitance vessels (P < 0.001) and a decrease in the capacity of pooling of blood in the calf (P < 0.0.5).
ACCESSION #
16347054

 

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