TITLE

THE EFFECT ON SERUM CONCENTRATION OF SODIUM, POTASSIUM, AND CHLORIDE DURING LONG TERM TREATMENT WITH SOME DIURETICS

AUTHOR(S)
Johansson, Bengt W.; Sievers, Jan
PUB. DATE
February 1966
SOURCE
Angiology;Feb1966, Vol. 17 Issue 2, p134
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Twenty-six patients were given trichlormethiazide for 6 months or more, and afterwards chlorthalidone for 6 months or longer. Sixteen patients were first given chlorthalidone and afterwards trichlormethiazide. The patients then received polythiazide for 6 months. As the diuretics used in this study are all known to be potent ones, we restricted the study to the effect on certain ion concentrations. The effect on the serum potassium concentration is shown in figure 2, and tables 2 and 3. During trichlormethiazide treatment, the K/s decreased from 4.16 to 3.86 mEq/1. A further decrease to 3.36 mEq/1 was seen during the ensuing chlorthalidone treatment. When chlorthalidone was first administrated the K/s decreased from 3.81 to 3.34 mEq/1. After subsequent trichlormethiazide administration the K/s rose to 3.42 mEq/1 and after the ensuing polythiazide treatment decreased to 3.33 mEq/1. These last two changes were not significant statistically. Urinary potassium loss, metabolic alkalosis, and other causes of hypokalemia are discussed.
ACCESSION #
16347000

 

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