Romanoff, Henry; Moran, Edgar
January 1966
Angiology;Jan1966, Vol. 17 Issue 1, p56
Academic Journal
Knitted, crimped Dacron patches were inserted in longitudinal incisions into the abdominal aortas of dogs. The changes within and around the graft area were studied at intervals up to 13 months. In the graft area, incorporation of tile patch within granulation tissue and regeneration of the lining endothelium was observed as early an 2 weeks after operation. After 1 month a new intima was formed over the patch, and the latter was incorporated in dense fibrous tissue. In the aortic wall, lateral to the graft area, changes were observed which may be understood as a response of the arterial wall to mechanical injury. Such lesions were seen within 2 weeks of insertion of the graft. They consisted of degeneration of elastic laminae and accumulation of acid mucopolysaccharide material within the media, fibrous intimal thickening and the presence of sudanophilic macrophages within the intima. Intimal fibrosis and elastic degeneration of the media were seen to persist until the end of the observation period.


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