Electrocardiographic and Hemodynamic Correlations in Primary Pulmonary Hypertension

Kanemoto, Nariaki
September 1988
Angiology;Sep1988, Vol. 39 Issue 9, p781
Academic Journal
In order to evaluate the pulmonary hemodynamics in primary pulmonary hypertension, the relation between the standard 12-lead electrocardiogram (ECG) and pulmonary hemodynamics as determined by right-heart catheterization was analyzed. Significant positive correlations were noted between amplitude of the R in V1, the R/S ratio in V1, and the pulmonary artery systolic pressure (r=0.46 and 0.50, respectively, p < 0.01). An amplitude of the R in V1 of more than 1.2 mV indicated a pulmonary artery systolic pressure of more than 90 mmHg with a sensitivity of 94% and a specificity of 47%. The cardiac index showed a significant positive relationship with amplitude of the R in V5 and V6 and the R/S ratio in V5 and V6 (r=0.46, 0.46, 0.39, and 0.48, respectively; each with a p < 0.01). Moreover, an �QRS = 100�, and either an SV6 = 0.7 mV, or R/SV6 = 2 indicated a cardiac index of < 2.8L/min/m2 with a sensitivity of 82% and 84% and a specificity of 86% and 100% respectively. This study suggests, therefore, that the 12-lead ECG is useful for the evaluation of the severity of pulmonary hypertension by its ability to predict pulmonary artery systolic pressure and cardiac index with clinically useful accuracy.


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