TITLE

Clinical and Pathological Comparison of Young Adult Women with Hepatocellular Carcinoma with and without Exposure to Oral Contraceptives

AUTHOR(S)
Hromas, Robert A.; Srigley, John; Murray, Lee
PUB. DATE
June 1985
SOURCE
American Journal of Gastroenterology;Jun1985, Vol. 80 Issue 6, p479
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We compared the clinical characteristics and histological classifications of young adult women with hepatocellular carcinoma with and without exposure to increased amounts of sex steroids in order to investigate the possibility that sex steroids changed the behavior of the tumor. Fifteen women were found to have a history of exposure to increased levels of sex steroids while 14 did not. One of the women in the exposed group had elements of adenoma next to her carcinoma, allowing speculation as to whether the malignancy arose from a previous adenoma. Statistically significant differences between the two groups were that the exposed group had a higher number of gravida (2.2 compared to 0.9, p = 0.013) and suffered tumor rupture with hemoperitoneum more frequently (4/15 compared to 0/4, p = 0.037). Trends worth noting were that the exposed group tended to survive longer, complain of pain and weight loss less frequently, and have lower α-fetoprotein levels. These findings indicate that exposure to sex steroids may change the clinical behavior of hepatocellular carcinoma, producing among other things a hypervascularity and tendency for hemoperitoneum.
ACCESSION #
16307485

 

Related Articles

  • Resolution of a Contraceptive-Steroid-Induced Hepatic Adenoma with Subsequent Evolution into Hepatocellular Carcinoma. Gordon, Stuart C.; Heddy, K. Rajender; Livinstone, Alan S.; Jeffers, Lennox K.; Schiff, Eugene R. // Annals of Internal Medicine;Oct86, Vol. 105 Issue 4, p547 

    Describes the case of a woman with contraceptive-steroid-induced hepatic adenoma that evolved into hepatocellular carcinoma. Diagnosis; Treatment; Discussion of the link between contraceptive steroids and hepatocellular carcinoma.

  • Transformation of Hepatic Cell Adenoma to Hepatocellular Carcinoma Due to Oral Contraceptive Use. Gyorffy, Edwin J.; Bredfeldt, James E.; Black, William C. // Annals of Internal Medicine;3/15/89, Vol. 110 Issue 6, p489 

    Reports on the case of a long-term user of oral contraceptives in whom a hepatic cell adenoma transformed into hepatocellular carcinoma. Medical profile of the patient; Result of the computer tomography screening of the patient; Evidence presented about the risk for hepatocellular carcinoma...

  • Changing trends in malignant transformation of hepatocellular adenoma. Olivier Farges // Gut;Jan2011, Vol. 60 Issue 1, p85 

    OBJECTIVE: Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to...

  • Cancer of the liver and the use of oral contraceptives. Forman, D.; Vincent, T.J.; Doll, R. // British Medical Journal (Clinical Research Edition);5/24/1986, Vol. 292 Issue 6532, p1357 

    Examines the association of oral contraceptives with the development of cancer of the liver among women in Great Britain. Increase of the relative risk for hepatocellular carcinoma; Use of death certificates as the primary source of information; Rarity of the disease.

  • Changing Epidemiology of Hepatocellular Adenoma in the United States: Review of the Literature. Chang, Charissa Y.; Hernandez-Prera, Juan C.; Roayaie, Sasan; Schwartz, Myron; Thung, Swan N. // International Journal of Hepatology;2013, p1 

    Hepatocellular adenoma (HCA) is a benign neoplasm arising from hepatocytes. There is evidence that the inflammatory subtype may be associatedwith obesity and alcohol use and thatmenwithmetabolic syndromemay be at risk formalignant transformation of HCA.We sought to explore the combined...

  • Oral contraceptives.  // Reactions Weekly;8/11/2007, Issue 1164, p18 

    This article discusses research being done on an adverse effect of oral contraceptives. It references a study by L. Sandonato and colleagues in the July 2007 issue of the "Journal of Medical Case." After long-term use of an oral contraceptive pill, a middle-aged woman developed hepatocellular...

  • Pathological Diagnosis of Hepatocellular Cellular Adenoma according to the Clinical Context. Bioulac-Sage, Paulette; Sempoux, Christine; Possenti, Laurent; Frulio, Nora; Laumonier, Hervé; Laurent, Christophe; Chiche, Laurence; Blanc, Jean Frédéric; Saric, Jean; Trillaud, Hervé; Le Bail, Brigitte; Balabaud, Charles // International Journal of Hepatology;2013, p1 

    In Europe and North America, hepatocellular adenomas (HCA) occur, classically, in middle-aged woman taking oral contraceptives. Twenty percent of women, however, are not exposed to oral contraceptives; HCA can more rarely occur in men, children, and women over 65 years. HCA have been observed in...

  • Histological evidence of carcinoma in a hepatic tumour associated with oral contraceptives. Davis, M.; Portmann, B.; Searle, M.; Wright, Ralph; Williams, Roger // British Medical Journal;11/29/1975, Vol. 4 Issue 5995, p496 

    Presents the histological evidence of carcinoma in hepatic tumour associated with oral contraceptives. Treatment by partial hepatectomy; Characteristics of a well-differentiated hepatocellular carcinoma; Descriptions as focal nodular hyperplasia.

  • Oral contraceptives and hepatocellular carcinoma. Neuberger, J.; Forman, D.; Doll, R.; Williams, Roger // British Medical Journal (Clinical Research Edition);5/24/1986, Vol. 292 Issue 6532, p1355 

    Examines the association of oral contraceptives with the development of hepatocellular carcinoma among women in Great Britain. Use of multivariate analysis; Increase in the risk of the disease; Induction of vascular changes.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics