Some asthma genotypes may not respond to β2 agonists

Batsford, N.
February 2005
Thorax;Feb2005, Vol. 60 Issue 2, p143
Academic Journal
The article reports that some asthma genotypes may not respond to β2 agonists. This was a prospective crossover trial comparing the use of salbutamol with placebo in 78 mild asthmatics aged 18-55 years. 50% had a genetic polymorphism resulting in homozygosity for arginine (Arg/Arg) at amino acid residue number 16 of the β2 agonist receptor instead of glycine (Gly/Gly), as in the other half. Each patient was matched with a patient from the other group. It appears that Gly/Gly patients respond to salbutamol while those with Arg/Arg seem to get better when salbutamol is withdrawn. It may be that the latter group actually responds to ipratropium.


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