Variation in Liver Histology in Alagille's Syndrome

Novotny, Nila Moore; Zetterman, Rowen K.; Antonson, Dean L.; Vanderhoof, Jon A.
June 1981
American Journal of Gastroenterology;Jun1981, Vol. 75 Issue 6, p449
Academic Journal
A previously undescribed variation in liver histology was observed in association with syndromatic neonatal jaundice, otherwise known as Alagille's syndrome. While hepatic ductular hypoplasia is thought to be characteristic of this disorder, we observed a patient who had all of the characteristic morphological features of Alagille's syndrome but whose liver biopsy demonstrated marked ductular proliferation more characteristic of biliary atresia. This histological feature has not been previously reported with Alagille's syndrome and hepatic ductular hypoplasia can no longer be considered characteristic of syndromatic neonatal jaundice.


Related Articles

  • Hepatic failure in a newborn with maternal peripartum exposure to echovirus 6 and enterovirus 71. Hung-Rong Yen, Anne; Reyin Lien; Ren-Huei Fu, Anne; Luan-Yin Chang // European Journal of Pediatrics;2003, Vol. 162 Issue 9, p648 

    Discusses the case of a premature infant with hepatic failure. Signs of jaundice; Maternal peripartum exposure to echovirus 6 and enterovirus 71; Liver function test; Blood exchange transfusion.

  • Hyperbilirubinemia, glucose-6-phosphate-dehydrogenase deficiency and Gilbert's syndrome. Galanello, R.; Cipollina, M. D.; Carboni, G.; Perseu, L.; Barella, S.; Corrias, A.; Cao, A. // European Journal of Pediatrics;1999, Vol. 158 Issue 11, p914 

    Abstract The pathogenesis of neonatal hyperbilirubinemia has not yet been completely defined in normal and glucose-6-phosphate-dehydrogenase (G6PD)-deficient newborns. The recent identification of a variant promoter in the gene encoding for the bilirubin uridine-diphosphoglucuronosyl-transferase...

  • Underlying Etiologies of Prolonged Icterus in Neonates. Najati, N.; Gharebaghi, M. M.; Mortazavi, F. // Pakistan Journal of Biological Sciences;2010, Vol. 13 Issue 14, p711 

    The purpose of this study was to determine underlying causes of prolonged neonatal icterus. Icterus or jaundice is an important common problem in neonatology. When this condition persists beyond 14 days, it is called prolonged or protracted neonatal icterus. Determining underlying causes of this...

  • Baby boon. Munson, Marty; Walsh, Therese // Prevention;Jul94, Vol. 46 Issue 7, p42 

    Discusses a study which found that tinmesoporphyrin (SnMP) may reduce the incidence of jaundice in newborns. Article in the January 1994 issue of `Pediatrics'; Bilirubin; Prematurity and the increased risk of jaundice.

  • How serious is newborn jaundice? Young, Stephanie // Glamour;Jul98, Vol. 96 Issue 7, p42 

    Presents information on how to monitor newborns for signs of jaundice. Why jaundice occurs in newborns; Seriousness of the disease; Effects of high levels of bilirubin.

  • Study: Early discharge not linked to jaundice.  // AHA News;06/02/97, Vol. 33 Issue 21, p5 

    Reports on the results of a study on the relationship of early hospital discharge to an increase in the occurrence of extreme jaundice among newborns in the United States.

  • Jaundice--to treat or not to treat? Boiter, Cynthia // Pediatrics for Parents;1996, Vol. 16 Issue 8, p9 

    Focuses on jaundice among newborn infants. Symptoms and causes; Tips on determining whether the infant needs medical attention or not.

  • A Report of 2 Cases of Green Pigmentation in the Primary Dentition Associated With Cholestasis Caused by Sepsis. Naudi, Antoniella Busuttil; Ammari, Amera B.; Fung, Diane E. // Journal of Dentistry for Children;Jan-Apr2008, Vol. 75 Issue 1, p91 

    Green pigmentation of teeth is uncommon but, when it occurs it is a cause of anxiety to the child and family. It also causes the child to lose self-esteem and increases social issues for the family. The purpose of this paper was to present the management of 2 unrelated patients who presented...

  • Farber's Disease Type IV Presenting With Cholestasis and Neonatal Liver Failure: Report of Two Cases. WILLIS, ASHA; VANHUSE, CHERIE; NEWTON, KIMBERLY P.; WASSERSTEIN, MELISSA; MOROTTI, RAFFAELLA A. // Pediatric & Developmental Pathology;Jul/Aug2008, Vol. 11 Issue 4, p305 

    We report 2 siblings diagnosed with Farber's disease type IV. Type IV is a subtype of Farber's disease that presents in the neonatal period and usually initially lacks the triad of symptoms, including painful and deformed joints, subcutaneous nodules, and hoarse cry, classically seen in the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics