Immunoglobulin Concentrations in the Duodenal Fluids of Infants and Children

Lebenthal, Emanuel; Clark, Barry
June 1981
American Journal of Gastroenterology;Jun1981, Vol. 75 Issue 6, p436
Academic Journal
A Study was conducted to determine whether pancreozymin and secretin affect the levels of immunoglobulins in duodenal fluid of children. The subjects consisted of 45 infants and children without gastrointestinal disease. Ig-A concentrations in duodenal fluid were significantly increased (P < 0.02) after secretin administration (2 U./kg.) as compared to resting fluid levels (18.3 ± 0.8 vs. 12.9 ± 1.1 mg./gm. protein). Secretin also produced a significant increase (P < 0.0002) in Ig-M duodenal fluid levels (25.5 ± 3.6 vs. 13.8 ± 1.4 mg./gm. protein). Duodenal fluid Ig-G concentrations were not significantly changed in response to secretin (30.7 ± ortopancreozymin (29.0 ± 0.8mg./gm. protein). Pancreozymin administtation (2 U./kg.) produced a significant decrease (P < 0.01) in Ig-A concentration (11.2 ± 0.8 mg./gm. protein) and a significant inctease (P < .0002) in the Ig-M levels of human duodenal fluid (20.8 ± 1.8 mg./gm. protein).


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