Helicobacter pyloriInfection: A Protective Factor for Esophageal Squamous Cell Carcinoma in a Taiwanese Population

Wu, Deng-Chyang; Wu, I-Chen; Lee, Jang-Ming; Hsu, Hon-Ki; Kao, Ein-Long; Chou, Shah-Hwa; Wu, Ming-Tsang
March 2005
American Journal of Gastroenterology;Mar2005, Vol. 100 Issue 3, p588
Academic Journal
AIM: Many researchers have reported the inverse relationship betweenHelicobacter pylori(H. pylori) infection and esophageal adenocarcinoma risk, but very few studies have examined the association betweenH. pyloriinfection and the development of esophageal squamous-cell carcinoma (ESCC). Therefore, the aim of this study is to evaluate the relationship betweenH. pyloriinfection and ESCC risk.METHOD: Subjects were cancer cases, pathologically proven to have ESCC, in two large medical centers in Kaohsiung metropolitan of southern Taiwan between August 2000 and May 2003. Controls were from the healthy subjects who lived in Kaohsiung metropolitan and voluntarily participated in one large multiyear of gene-environmental study. In total, 127 cases (116 males and 11 females) and 171 controls (161 males and 10 females) were recruited in the same period of time for interviews.H. pyloriseropositivity was determined by an enzyme-linked immunosorbant assay measuring IgG.RESULTS: A total of 28 (22.1%) and 74 (43.3%) out of 127 cases and 171 controls, respectively, had positiveH. pyloriinfection. After adjusting for other covariates, subjects with positiveH. pyloriinfections had a significantly reduced risk (adjusted odds ratio (AOR)= 0.51; 95% CI= 0.27–0.96;p= 0.037) of developing ESCC than those without. This result was even more pronounced in the groups of younger subjects, nonsmokers, or nondrinkers. In addition, among the 117 cancer patients who provided information about site of cancer lesion, the present study found that subjects with cancer lesions in the lower third of the esophagus had significantly fewer positiveH. pyloriinfections (AOR= 0.34; 95% CI= 0.14–0.80;p= 0.013) than controls.CONCLUSION: Our findings suggest thatH. pyloriinfection may protect against the development of ESCC. Additional studies are needed to confirm these findings.(Am J Gastroenterol 2005;100:588–593)


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