TITLE

Interleukin 18 promoter polymorphisms are not strongly associated with type I diabetes in a UK population

AUTHOR(S)
Martin, R.J.L.; Savage, D.A.; Carson, D.J.; Maxwell, A.P.; Patterson, C.C.
PUB. DATE
March 2005
SOURCE
Genes & Immunity;Mar2005, Vol. 6 Issue 2, p171
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Interleukin 18 (IL18) is a proinflammatory cytokine whose levels are increased in the subclinical stage of insulin-dependent (type I) diabetes mellitus. Previous case-control studies have reported associations between IL18-607C>A and-137G>C promoter polymorphisms and type I diabetes. We performed case-control and family-based association studies employing Pyrosequencing to assess if these IL18 polymorphisms are also associated with the development of type I diabetes in the Northern Ireland population. The?2 analysis of genotype and allele frequencies for the IL18 polymorphisms in cases (n=433) vs controls (n=426) revealed no significant differences (P>0.05). Assessment of allele transmission distortion from informative parents to affected offspring also failed to confirm previously reported associations. Stratification of these analyses for age-at-onset and HLA-DR type did not reveal any significance associations. In conclusion, our data do not support the strong positive associations of IL18 promoter polymorphisms with type I diabetes reported in previous smaller studies.Genes and Immunity (2005) 6, 171-174. doi:10.1038/sj.gene.6364161 Published online 23 December 2004
ACCESSION #
16272435

 

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