TITLE

Celiac Disease: Does Hyposplenism Predispose to the Development of Malignant Disease?

AUTHOR(S)
O'Grady, J. G.; Stevens, F. M.; McCarthy, C. F.
PUB. DATE
January 1985
SOURCE
American Journal of Gastroenterology;Jan1985, Vol. 80 Issue 1, p27
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Splenic size and function was assessed in eight patients with celiac disease and coexisting malignancy (six had small bowel lymphoma and two gastric adenocarcinoma). The size of the spleen was reduced in four of seven patients as seen at autopsy or radionucleotide scanning. Splenic function was studied using "pitted" erythrocyte counts, platelet counts, and Howell-Jolly bodies and was impaired in five of eight patients. Malignant disease developed in some celiacs with normal splenic size and function. Splenic function as measured by pitted erythrocyte counts was similar in the celiac patients with malignancy and appropriately matched nonmalignant celiacs. We conclude that hyposplenism in celiac disease does not influence the development of malignant disease.
ACCESSION #
16266076

 

Related Articles

  • Acute Toxicity and Blood Profile of Adult Clarias gariepinus Exposed to Lead Nitrate. Adeyemo, Olanike K.; Ajani, Funmilola; Adedeji, Olufemi B.; Ajiboye, Olajide O. // Internet Journal of Hematology;2008, Vol. 4 Issue 2, p6 

    Changes in Clarias gariepinus' blood cells were investigated after 96-h of exposure to lead. Ninety (90) Clarias gariepinus with average weight of 262.2g and average length of 30.8 were divided into 5 groups (A-E) at six (6) fish per group and in triplicates after being acclimatized for 14 days....

  • Virus Inactivation in the 1990s- and into the 21st Century Part 2, Red Blood Cells and Platelets. Sofer, Gail // BioPharm International;Aug2002, Vol. 15 Issue 8, p42 

    Discusses the different viral inactivation methods. Methods used for virus inactivation in red blood cells; Methods for inactivating virus in platelets. INSET: Virus Abbreviations.

  • microthrombus.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1467 

    A definition of the term "microthrombus," which refers to a microscopic bundle of fibrin, platelets and red blood cells, is presented.

  • Massa alimentícia sem glúten com elevado teor proteico obtida por processo convencional. Schmiele, Mareio; Zafalon Jaekel, Leandra; Mello Garrido Ishida, Patricia; Yoon Kil Chang; Steel, Caroline Joy // Ciência Rural;mai2013, Vol. 43 Issue 5, p908 

    Celiac individuals require a gluten free diet, which includes products such as rice pasta. However, this cereal has lower protein content, when compared with other cereals, and poor cooking and texture technological characteristics for pasta. The aim of this research was the development of rice...

  • Rational Alternatives to the Use of Whole Blood. Westphal, Robert G. // Annals of Internal Medicine;Jun72, Vol. 76 Issue 6, p987 

    Describes the nature and alternative use of blood components. Information on packed red blood cells; Elements of platelet concentrates; Preparation of cryoprecipitate; Contents of whole blood.

  • Reply to the letter by H. Mawatari et al. regarding 'Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly'. Ikeda, Hitoshi; Tejima, Kazuaki; Masuzaki, Ryota; Yatomi, Yutaka; Koike, Kazuhiko // Journal of Gastroenterology;May2012, Vol. 47 Issue 5, p608 

    No abstract available.

  • POSSIBLE PARANEOPLASTIC BLOOD ANALYSIS AND LUNG CANCER. Arslanagić, Selma; Arslanagić, Rusmir; Karabeg, Reuf; Arslanagić, Naima // Medical Journal;jul-sep2011, Vol. 17 Issue 3, p210 

    In this study, we examined the correlation of platelet count with white blood cell count, erythrocyte count, hemoglobin value and erythrocytes sedimentation rate in patients with lung cancer before beginning any therapy. We have shown a negative correlation between platelets count and...

  • Screening for Celiac Disease in First-Degree Relatives of Patients with Celiac Disease by Lactulose/Mannitol Test. Vogelsang, Harald; Wyatt, John; Penner, Edward; Lochs, Herbert // American Journal of Gastroenterology;Oct1995, Vol. 90 Issue 10, p1838 

    Objectives: In first-degree relatives of celiac patients, the risk of oligosymptomatic celiac disease is elevated. These individuals therefore also have a higher potential for malignancy or nutritional deficiencies. Lactulose/ mannitol permeability is increased in untreated celiac patients and...

  • Adenocarcinoma of the Duodenum in a Patient with Nontropical Sprue. Levine, Milton L.; Dorf, Barry S.; Bank, Simmy // American Journal of Gastroenterology;Sep1986, Vol. 81 Issue 9, p800 

    Celiac sprue is associated with an increased risk of malignant lymphoid tumors. A patient is presented with celiac disease and adenocarcinoma of the duodenum; this association suggests that a careful search for complicating malignant tumors be undertaken in those patients with sprue whose...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics