A Comparison of Cimetidine and Sucralfate in the Treatment of Bleeding Peptic Ulcers

Goldfarb, Joel P.; Czaja, Mark J.
January 1985
American Journal of Gastroenterology;Jan1985, Vol. 80 Issue 1, p5
Academic Journal
To assess the efficacy of cimetidine versus sucralfate in terminating or preventing further bleeding of peptic ulcers, patients presenting with bleeding from duodenal or gastric ulcers were openly randomized to receive cimetidine 1800 mg/day or sucralfate 8 g/day for a 1-wk period. All patients were endoscoped within 8 h of their presentation with bleeding. Patients were included only if they had evidence of severe or active bleeding. After randomization, patients were assessed for transfusion requirements, continued bleeding and rebleeding, the need for emergency surgery, and medication side effects. Ten patients were randomized to each group. Mean transfusion requirements were the same in both groups. In the cimetidine group, two patients rebled and two bad serious side effects. In the sucralfate group, two patients had rebleeding requiring surgery, and there were no side effects of therapy. Sucralfate may be an alternative to cimetidine in treating bleeding peptic ulcers.


Related Articles

  • Stopping the haemorrhage from peptic ulcers. Young, A.E. // British Medical Journal (Clinical Research Edition);2/20/1982, Vol. 284 Issue 6315, p530 

    Examines the haemorrhage from peptic ulcers. Treatment of the blood loss; Impact of somatostatin on gastrin release; Reduction of the blood flow in the coeliac axis.

  • Importance of hypovalaemic shock and endoscopic signs in predicting recurrent haemorrhage from peptic ulceration: a prospective evaluation. Bornman, P.C.; Theodorou, N.A.; Shuttleworth, R.D.; Essel, H.P.; Marks, I.N. // British Medical Journal (Clinical Research Edition);7/27/1985, Vol. 291 Issue 6490, p245 

    Examines the importance of hypovolemic shock and endoscopic signs to predict hemorrhage in patients with peptic ulceration. Verification of the endoscopic signs of the disease; Interval of hemorrhage occurrence to patients; Assessment of systolic blood pressure of patients with or without shock.

  • Gastric Lipoma Presenting as Peptic Ulcer: Case Report and Review of the Literature. Chu, Anthony G.; Clifton, James A. // American Journal of Gastroenterology;Oct1983, Vol. 78 Issue 10, p615 

    A 61-year-old housewife was diagnosed as having peptic ulcer disease for a period of 2 years. During this time she had episodes of abdominal cramping, dyspepsia., and one episode of severe upper gastrointestinal bleeding. She was subsequently found to have a large gastric lipoma. Gastric lipoma,...

  • Continuing Medical Education Questions: March 2013. DeVault, Kenneth R; Mehta, Paresh P; Albeldawi, Mazen; Kumaravel, Arthi; Macaron, Carole // American Journal of Gastroenterology;Mar2013, Vol. 108 Issue 3, p346 

    A continuing medical education quiz on mortality and comorbodity in patients suffering from peptic ulcer bleeding is presented.

  • Psychosocial factors associated with peptic ulcer in aged persons. Furuse, Midori; Kumano, Hiroaki // Psychological Reports;Dec99 Part 1, Vol. 85 Issue 3, p761 

    Studies the relationship between psychosocial factors and the occurrence and aggravation of peptic ulcer on elderly patients. Significant association between occurrence of peptic ulcer with having an occupation and low exercise practice in men; Independent association of specific psychosocial...

  • Giant Prepyloric Ulcer Haemorrhage: Patient Characteristics, Treatment, and Outcome in 2003-2012. Peetsalu, Margot; Kirsim√§gi, √úlle; Peetsalu, Ants // Ulcers;2014, p1 

    The aim of the study was to characterize patients with giant prepyloric ulcer haemorrhage, their treatment, and outcome. The data for 929 peptic ulcer haemorrhage (PUH) patients were divided into three groups according to ulcer location: group I: 165 prepyloric ulcer patients, group II: 353...

  • Management of Acute Bleeding from a Peptic Ulcer. Gralnek, Ian M.; Barkun, Alan N.; Bardou, Marc // New England Journal of Medicine;8/28/2008, Vol. 359 Issue 9, p928 

    The article presents an overview of the proper management of acute bleeding from a peptic ulcer, which is a prevalent and clinically significant condition that has implications for global health care costs. A discussion of the epidemiology of acute upper gastrointestinal hemorrhage in the United...

  • Nursing decisions: a patient with a bleeding ulcer. Stillman, Margot J.; de Tornyay, Rheba // RN;Jun78, Vol. 41 Issue 6, p65 

    Discusses the nursing management of a patient with a bleeding ulcer. Medical background of the patient; Information on peptic ulcer disease; Differences between duodenal and gastric ulcers; Medical therapy for ulcer disease.

  • Pneumopericardium Associated with a Peptic Ulcer. Andrianov, Alexandre; Nissenbaum, Michael A. // New England Journal of Medicine;12/22/2011, Vol. 365 Issue 25, p2412 

    The article describes the case of a 63-year-old man with a history of peptic ulcer and recent use of nonsteroidal antiinflammatory medications, who was presented with chest pain and an acute onset of shortness of breath.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics