A Comparative Study of Pentazocine and Meperidine on the Biliary Passage Pressure

Greenstein, Adrian J.; Kaynan, Arieh; Singer, Adolf; Dreiling, David A.
October 1972
American Journal of Gastroenterology;Oct1972, Vol. 58 Issue 4, p417
Academic Journal
A controlled study has been carried out comparing the effects of pentazocine and meperidine upon the intraductal passage pressures of the biliary system. The study has shown that pentazocine has an immediate, rapid and significant effect upon the choledochal sphincter passage pressure. A maximum pressure increase of approximately 100 per cent at 20 minutes occurred synchronously with each drug. Although these dosages administered are approximately equianalgesic, it is not claimed that they are identical. The response of the individual patient appears to be determined by the biological propensity of the sphincter of that particular patient and in some individuals a secondary peak occurs.


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