Chlorpromazine Therapy and Functional Large Bowel Obstruction

Davis, J. Terrance; Nusbaum, Moreye
December 1973
American Journal of Gastroenterology;Dec1973, Vol. 60 Issue 6, p635
Academic Journal
A case report of colonic atony, presenting as mechanical intestinal obstruction, is documented where exploratory laparotomy ruled out any organic cause of obstruction. The use of chlorpromazine in high doses, which is known to produce gastrointestinal ileus, suggests that such therapy may have been a causative factor in the production of the clinical picture. In view of this possible side-effect, it is suggested that patients on chlorpromazine therapy he closely watched for signs of gastrointestinal dysfunction and that the drug be promptly discontinued if such signs are noted.


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