Hyperglucagonemia--A Partial Explanation for the Increased Amylase/Creatinine Clearance in Pancreatitis

Santo, M.; Aderka, D.; Kanter, Y.; Enat, R.; Barzilai, D.
February 1983
American Journal of Gastroenterology;Feb1983, Vol. 78 Issue 2, p99
Academic Journal
Hyperglucagonemia accompanies several clinical conditions characterized by increased amylase/creatinine clearance. We tested the hypothesis that glucagon may be responsible for this augmented clearance. Therefore, a constant glucagon infusion was given to eight volunteers in order to attain physiological levels comparable to those obtained during acute pancreatitis. The amylase/creatinine clearance increased from 0.84 ± 0.8% to a mean of 1.30 ± 1.14% (p < 0.001). This was, however, less than the clearance of 2.94 ± 0.23% observed during acute pancreatitis. The rise in amylase clearance during acute pancreatitis is, therefore, only partially explained by the hyperglucagonemia.


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