TITLE

Free Perforation in Crohn's Disease: A Report of 33 Cases and Review of Literature

AUTHOR(S)
Katz, Seymour; Schulman, Nathan; Levin, Leroy
PUB. DATE
January 1986
SOURCE
American Journal of Gastroenterology;Jan1986, Vol. 81 Issue 1, p38
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Thirty-three patients with free perforation in Crohn's disease are described. There are 14 males and 19 females in this series with ages ranging from 14 to 79 years. The sites of perforation were 22 of the ileum, nine colonic, one jejunal, and one gastroduodenal. Toxic megacolon coexisted in two. Reperforation occurred in three. Free perforation was the presenting sign of the disease in three. Steroid therapy coexisted in 16 patients but in five was administered for less than 10 days before perforation. Obstruction coexisted in only three patients. There were two deaths. Twenty-two patients were treated with resection and diversion, nine patients with resection and drainage, and two with plication only. No relationship between steroid therapy, duration of disease, toxic dilatation, or obstruction with perforation could be established. Resection of the perforated disease segment is necessary when possible. In contradistinction to previous literature, free perforation in Crohn's disease is not as unusual as heretofore believed.
ACCESSION #
16224455

 

Related Articles

  • Metastatic Vulvar Ulceration in Crohn's Disease. Reyman, Lynn; Milano, Andrew; Demopoulos, Rita; Mayron, Jacob; Schuster, Steven // American Journal of Gastroenterology;Jan1986, Vol. 81 Issue 1, p46 

    Presents two cases of patients with vulvar ulcerations and Crohn's disease. Condition of the patients; Information on Crohn's disease; Treatment modalities of metastatic ulcers associated with Crohn's disease.

  • A case of perforation and fistula formation resulting from metallic stent for sigmoid colon stricture in Crohn’s disease. Wada, H.; Mochizuki, Y.; Takazoe, M.; Matsuhashi, N.; Kitou, F.; Fukushima, T. // Techniques in Coloproctology;Apr2005, Vol. 9 Issue 1, p53 

    A 52-year-old male was diagnosed with Crohn’s disease at the age of 25 years. Thereafter, he underwent three operations for intestinal strictures or fistula. A self-expanding metallic stent was inserted into the sigmoid colon stricture endoscopically in November 1999. Thirty two months...

  • Prognosis of Crohn's disease.  // British Medical Journal (Clinical Research Edition);5/2/1981, Vol. 282 Issue 6274, p1415 

    Presents a study on patients with Crohn's disease. Details of the medical approach in treating Crohn's disease; Incidence and causes of death in patients suffering from Crohn's disease; Association between Crohn's disease and carcinoma of the gastrointestinal tract.

  • The Role of Thiopurines in Reducing the Need for Surgical Resection in Crohn's Disease: A Systematic Review and Meta-Analysis. Chatu, Sukhdev; Subramanian, Venkataraman; Saxena, Sonia; Pollok, Richard CG // American Journal of Gastroenterology;Jan2014, Vol. 109 Issue 1, p23 

    Objectives:The thiopurine (TP) analogs azathioprine and mercaptopurine have proven efficacy in inducing and maintaining clinical remission in Crohn's disease (CD). Their impact on the long-term need for surgery is uncertain since studies have reported conflicting results. The aim of this...

  • Sulfasalazine Pneumonitis. Yaffe, Bruce H.; Korelitz, Burton I. // American Journal of Gastroenterology;Aug1983, Vol. 78 Issue 8, p493 

    A man with alleged Crohn's disease of the terminal ileum was started on sulfasalazine. Five weeks later he developed progressive cough, shortness of breath, and fever associated with peripheral eosinophilia and bilateral pulmonary infiltrates. After withdrawal of sulfasalazine all abnormalities...

  • Somatropin.  // Reactions Weekly;9/15/2007, Issue 1169, p25 

    The article describes the case of a woman with Crohn's disease who developed ileal perforation during treatment with somatropin. The patient received up to 1.04 mg/day of self-administered injections of somatropin from September 2002 to October 2003. She developed severe pain in her right lower...

  • The Diagnostic Value of Serum Lysozyme Activity in Inflammatory Bowel Disease. Ayulo, Julio A.; Chi-Cheng Chen; Pelot, Daniel; Berk, J. Edward // American Journal of Gastroenterology;Jul1977, Vol. 68 Issue 1, p71 

    Serum lysozyme (muramidase) activity was determined by the Lyso-Plate diffusion technic in 419 subjects consisting of normal persons and patients with Crohn's disease, ulcerative colitis, nonspecific diarrhea and various other disorders. Lysozyme activity in the normal subjects did not exceed...

  • Hyperplastic-Like Mucosal Change in Crohn’s Disease: An Unusual Form of Dysplasia? Kilgore, Sony P.; Sigel, Jessica E.; Goldblum, John R. // Modern Pathology;Jul2000, Vol. 13 Issue 7, p797 

    Patients with Crohn’s disease are at increased risk of developing intestinal adenocarcinoma. Dysplasia is both a marker and a precursor of adenocarcinoma in this setting. In a review of our cases of Crohn’s-related adenocarcinoma, we noted a peculiar hyperplastic-like mucosal...

  • Predictors of response to enteral nutrition in abdominal enterocutaneous fistula patients with Crohn's disease. Yan, D; Ren, J; Wang, G; Liu, S; Li, J // European Journal of Clinical Nutrition;Aug2014, Vol. 68 Issue 8, p959 

    Background/Objectives:Enterocutaneous fistula (ECF) is a serious complication of Crohn's disease (CD). Enteral nutrition (EN) is believed as one of therapeutic strategies of CD. This study is dedicated to identify predictors of response to EN in CD, which may lead to a better selection of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics