Duodenal Somatostatinoma with Psammoma Bodies: An Immunohistochemical and Ultrastructural Study

Taccagni, G. L.; Carlucci, M.; Sironi, M.; Cantaboni, A.; Di Carlo, V.
January 1986
American Journal of Gastroenterology;Jan1986, Vol. 81 Issue 1, p33
Academic Journal
We report a case of malignant somatostatinoma of the ampulla of Valet in a 38-year-old woman with diabetes and cholelithiasis. Immunohistochemistry showed that tumor cells contained only somatostatin and electron microscopy revealed D-type granules in their cytoplasm. Psammoma bodies were numerous and appeared to originate in the cytoplasm of somatostatin producing cells. A review of the literature reveals that somatostatinomas with psammoma bodies are found only in the duodenum and do not produce significant amounts of peptides other than somatostatin.


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