Comparison of a Rapid Hepatitis B Immunization Schedule to the Standard Schedule for Adults

Marsano, Luis S.; Greenberg, Richard N.; Kirkpatrick, Robert B.; Zetterman, Rowen K.; Christiansen, Abigail; Smith, Daniel J.; DeMedina, Maria D.; Schiff, Eugene R.
January 1996
American Journal of Gastroenterology (Springer Nature);Jan1996, Vol. 91 Issue 1, p111
Academic Journal
We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 µg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≤100 mIU/mL at a similar rate, but a higher seroprotection rate at ≤500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti-hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.


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