TITLE

Chronic obstructive pulmonary disease · 3: Experimental animal models of pulmonary emphysema

AUTHOR(S)
Mohadeva, R.; Shapiro, S. D.
PUB. DATE
October 2002
SOURCE
Thorax;Oct2002, Vol. 57 Issue 10, p908
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Animal studies have been critical in shaping contemporary views regarding the pathogenesis of emphysema. The intratracheal instillation of the plant proteinase papain into rats resulted in emphysema. Intrapulmonary challenge with injurious proteins, chemicals, particulates, and other compounds into lungs of animals has been used to cause emphysema directly. Exogenous administration of proteinases, chemicals, particulates, and exposure to cigarette smoke result in features characteristic of human chronic obstructive pulmonary disease.
ACCESSION #
16181817

 

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