Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis

Oioo, J. C.; Mulrennan, S. A.; KasteIik, J. A.; Morice, A. H.; Redington, A. E.
January 2005
Thorax;Jan2005, Vol. 60 Issue 1, p22
Academic Journal
Background: It has been proposed that the ph of airway lining fluid may regulate the fractional exhaled concentration of nitric oxide (FENO) in respiratory disease. Methods: FENO, exhaled breath condensate (BC) ph, and BC concentrations of nitrite plus nitrate (NO2/NO3) were compared in 12 subjects with stable asthma, 18 with stable cystic fibrosis (CF), and 15 healthy control subjects. Eight of the CF patients were studied on a separate occasion at the start of a pulmonary exacerbation. Results: FENO was significantly greater in asthmatic subjects than in control subjects (mean 35 v 9 ppb, p<0.001). EBC ph, however, was similar in the asthmatic and control groups (median 522 v 6.08, p = 0.23). Levels of NO2/NO3 were on average higher in EBC samples from asthmatic subjects, but the difference was not significant. In patients with stable CF both the FENO (mean 4 ppb, p<0.001) and EBC ph (median 5.77, p=0.003) were lower than in the control group. Levels of EBC NO2/NO3 (median 29.9 pM; p =0.002) in patients with stable CF, in contrast, were significantly higher than in control subjects. During CF exacerbations, EBC ph was further reduced (median 5.30, p,= 0.017) but FENO and NO2/NO3 were unchanged. Conclusions: These findings demonstrate a dissociation between BC ph and FENO in inflammatory airways disease.


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