TITLE

Relationship between exposure to domestic allergens and bronchial hyperresponsiveness in non-sensitised, atopic asthmatic subjects

AUTHOR(S)
Langley, S. J.; Goldthorpe, S.; Craven, M.; Woodcock, A.; Custovic, A.
PUB. DATE
January 2005
SOURCE
Thorax;Jan2005, Vol. 60 Issue 1, p17
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: The effect of exposure to allergens not causing sensitisation in atopic asthmatic subjects has not previously been studied. A study was undertaken to assess the degree of asthma severity (measured by spirometry, airway reactivity and exhaled nitric oxide) in atopic asthmatic patients not sensitised to the domestic allergen to which they were exposed. Methods: Dust samples were collected from the living room carpet and mattress in the homes of 248 subjects and dust mite, cat and dog allergen concentrations were measured. Spirometry, non-specific bronchial reactivity (BR), and exhaled nitric oxide (eNO) were ascertained. Patients' sensitisation status was assessed by skin prick testing. Results: Adult atopic asthmatics not sensitised to mite but exposed to high levels of mite allergen had significantly more severe BR than subjects not exposed to high levels of mite (PD20, geometric mean (GM) 0.21 mg (95% CI 0.09 to 0.47) v 0.86 mg (95% CI 0.44 to 1.67), mean ratio difference 4.1 (95% Cl 1.5 to 11.4), p = 0.008). Subjects not sensitised but exposed to high levels of dog allergen also had significantly more severe BR than subjects not exposed (PD20 GM 0.16 v 0.52 mg, mean ratio difference 3.3 (95% CI 1.2 to 9.2), p = 0.01). The differences in BR between these groups were still significant after adjusting for confounding factors. This effect of greater airway reactivity was not seen in subjects exposed but not sensitised to cat allergens. Conclusion: Atopic asthmatic subjects who are exposed to high levels of dust mite or dog allergens but not sensitised to these allergens have evidence of increased airway reactivity.
ACCESSION #
16163700

 

Related Articles

  • Tokat bölgesinde astım hastalarında prik test duyarlılığı ve duyarlılığın solunum fonksiyon testleri ile iliÅŸkisi. Yilmaz, Ayşe; İnönü, Handan; Öcal, Serpil Göçmen; Çelikel, Serhat; Doruk, Sibel; Etikan, Ilker; Seyfikli, Zehra // Asthma Allergy Immunology / Astim Allerji Immunoloji;May2009, Vol. 7 Issue 1, p44 

    Objective: The aim of this study was to evaluate the distribution of skin prick tests (SPT) and the relationship of SPT results with age, gender and pulmonary function tests (PFT) in patients followed up with asthma in the chest diseases department of our hospital. Materials and Methods: Age,...

  • Inhaler Competence and Patient Satisfaction with Easyhaler: Results of Two Real-Life Multicentre Studies in Asthma and COPD. Gálffy, Gabriella; Mezei, Györgyi; Németh, Gyula; Tamási, Lilla; Müller, Veronika; Selroos, Olof; Orosz, Marta // Drugs in R&D;2013, Vol. 13 Issue 3, p215 

    Objective: The aim of this study was to investigate patients' inhaler competence and satisfaction with the Easyhaler dry powder inhaler. Design: Two open, uncontrolled, non-randomised studies. Setting: Real life based on patients attending 56 respiratory clinics in Hungary. Participants:...

  • Maria's review: all as expected? Dhami, Julie // Practice Nurse;4/10/2009, Vol. 37 Issue 7, p33 

    The article presents a case study of a 61-year-old woman with asthma. During her childhood, she required frequent hospitalizations for it. Her present medications are beclometasone by inhaler and salbutamol. The article discusses the results of spirometry testing, conditions that could cause the...

  • Early life origins of chronic obstructive pulmonary disease. C Svanes // Thorax;Jan2010, Vol. 65 Issue 1, p14 

    BACKGROUND: Early life development may influence subsequent respiratory morbidity. The impact of factors determined in childhood on adult lung function, decline in lung function and chronic obstructive pulmonary disease (COPD) was investigated. METHODS: European Community Respiratory Health...

  • ALLERGEN EXPOSURE AND THE DEVELOPMENT OF ASTHMA. Sporik, R.; Platts-Mills, T. A. E. // Thorax;Sep2001 Supp, Vol. 56, pii58 

    Background: In a prospective birth cohort study, we assessed the relevance of mite and cat allergen exposure for the development of childhood asthma up to age 7 years. Methods: Of 1314 newborn infants enrolled in five German cities in 1990, follow-up data at age 7 years were available for 939...

  • Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. O'Driscoll, B. Ronan; Hopkinson, Linda C.; Denning, David W. // BMC Pulmonary Medicine;2005, Vol. 5, p4 

    Background: Multiple studies have linked fungal exposure to asthma, but the link to severe asthma is controversial. We studied the relationship between asthma severity and immediate type hypersensitivity to mold (fungal) and non-mold allergens in 181 asthmatic subjects. Methods: We recruited...

  • Small airways function and molecular markers in exhaled air in mild asthma. Battaglia, S.; den Hertog, H.; Timmers, M. C.; Lazeroms, S. P. G.; Vignola, A. M.; Rabe, K. F.; Bellia, V.; Hiemstra, P. S.; Sterk, P. J. // Thorax;Aug2005, Vol. 60 Issue 8, p639 

    Background: Several studies suggest that the periphery of the lung is the major site of inflammation in asthma. Fractional exhaled nitric oxide (FeNO) and 8-isoprostane have been proposed as biomarkers of inflammation and oxidative stress. We therefore hypothesised that small airway dysfunction...

  • Two patients with occupational asthma who returned to work with dust respirators. Obase, Yasushi; Shimoda, Terufumi; Mitsuta, Kazuko; Matsuse, Hiroto; Kohno, Shigeru // Occupational & Environmental Medicine;Jan2000, Vol. 57 Issue 1, p62 

    Objectives: To assess the efficacy of dust respirators in preventing asthma attacks in patients with occupational asthma (asthma induced by buckwheat flour or wheat flour). Methods: The effect of the work environment was examined in two patients with occupational asthma with and without the use...

  • Putative roles of circulating resistin in patients with asthma, COPD and cigarette smokers. Al Mutairi, Sana S.; Mojiminiyi, Olusegun A.; Shihab-Eldeen, Aida; Al Rammah, Tahani; Abdella, Nabila // Disease Markers;2011, Vol. 31 Issue 1, p1 

    Aims: To investigate the hypothesis that circulating resistin reflects the degree of pulmonary inflammation, this study explores putative roles of resistin in patients with acute and stable inflammatory obstructive airway diseases and cigarette smokers. Methods: We determined complements C3, C4,...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics