Granuloma formation in the different phenotypes of Crohn's disease

Hofstaedler, F.
February 2005
Gut;Feb2005, Vol. 54 Issue 2, p180
Academic Journal
This article discusses granuloma formation in the different phenotypes of Crohn's disease. The immunological and molecular knowledge base' in idiopathic chronic inflammatory bowel disease has seen a tremendous increase over the past few years. Laboratory application of sophisticated new methodologies has revealed a plethora of agonistic and antagonistic factors involved in the pathogenesis of both ulcerative colitis and Crohn's disease. Some of the newly discovered pathways have been utilized to develop new therapeutic strategies and molecular genetic studies in particular have provided fascinating new insights into the problems of genetic host susceptibility.


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