TITLE

GENOTYPES AND PHENOTYPES IN CROHN'S DISEASE: DO THEY HELP IN CLINICAL MANAGMENT

AUTHOR(S)
Gasche, C.; Grundtner, P.
PUB. DATE
January 2005
SOURCE
Gut;Jan2005, Vol. 54 Issue 1, p162
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports that the various subforms of Crohn's disease have not been recognised until recently. Historically, colonic Crohn's disease was not distinguished from ulcerative colitis. Approximately 30 years ago, the first studies highlighted the diverse natural history of colonic and ileal Crohn's disease. Inherent differences in disease behaviour were later recognised by a group of physicians at Mount Sinai Hospital in New York. Biological discrimination between various subgroups of Crohn's patients led to a proposal for a phenotypic classification, which was taken up and further developed and evaluated by an international working group, leading to the Vienna classification. Accordingly, Crohn's disease is separated into three categories such as age at diagnosis, location, and behaviour.
ACCESSION #
16163240

 

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