TITLE

Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin

AUTHOR(S)
Asakawa, A.; Inui, A.; Fujimiya, M.; Sakamaki, R.; Shinfuku, N.; Ueta, Y.; Meguid, M. M.; Kasuga, M.
PUB. DATE
January 2005
SOURCE
Gut;Jan2005, Vol. 54 Issue 1, p18
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background/Aims: The gastric peptide ghrelin, an endogenous ligand for growth-hormone secretagogue receptor, has two major molecular forms: acylated ghrelin and desacyl ghrelin. Acylated ghrelin induces a positive energy balance, while desacyl ghrelin has been reported to be devoid of any endocrine activities. The authors examined the effects of desacyl ghrelin on energy balance. Methods: The authors measured food intake, gastric emptying, c-Fos expression in the hypothalamus, and gene expression of hypothalamic neuropeptides in mice after administration of desacyl ghrelin. To explore the effects of long term overexpression of desacyl ghrelin, transgenic mice that overexpressed desacyl ghrelin were created. Results: Administration of desacyl ghrelin decreased food intake and gastric emptying rate through an action on the paraventricular nucleus and the arcuate nucleus in the hypothalamus. Gene expression of anorexigenic cocaine and amphetamine regulated transcript and urocortin in the hypothalamus was increased by desacyl ghrelin. Desacyl ghrelin overexpressing mice exhibited a decrease in body weight, food intake, and fat pad mass weight accompanied by moderately decreased linear growth. Gastric emptying was also decreased in desacyl ghrelin overexpressing mice. Conclusions: These findings indicate that in contrast to acylated ghrelin, desacyl ghrelin induces a negative energy balance by decreasing food intake and delaying gastric emptying. The effect is mediated via the hypothalamus. Although derived from the same precursor, the inverse effects of these two peptides suggest that the stomach might be involved as an endocrine organ in the regulation of the energy balance.
ACCESSION #
16163220

 

Related Articles

  • RELATION OF PLASMA GHRELIN LEVELS WITH LEPTIN IN OBESE CHILDREN AND ADOLESCENTS. Hassanain, Amal I.; Amer, Ahmed F.; El-Sonbaty, Marwa M.; Hassan, Amgad K.; Salem, Samar M.; Morcos, William // International Journal of Academic Research;Jan2012, Vol. 4 Issue 1, p119 

    Background: Ghrelin and leptin are two hormones playing an important role in the regulation of food intake and body weight. Ghrelin and leptin levels are influenced by body fat, pubertal stage and possibly insulin resistance (IR). The aim of our study was: to compare fasting ghrelin and leptin...

  • Influence of short- and long-term treadmill exercises on levels of ghrelin, obestatin and NPY in plasma and brain extraction of obese rats. Jun Wang; Chen Chen; Rui-Yuan Wang // Endocrine (1355008X);Apr2008, Vol. 33 Issue 1, p77 

    Abstract  This study aims to clarify the effects of exercise on levels of appetite regulatory hormones in plasma and hypothalamus of obese rats. Diet-induced obese rats undergo short- (40 min) and long-term (40 min, 5 days/week for 8 weeks) exercises. The rats ran at a speed of...

  • Leptin downregulates heat shock protein-70 (HSP-70) gene expression in chicken liver and hypothalamus. Figueiredo, Denise; Gertler, Arieh; Cabello, Gérard; Decuypere, Eddy; Buyse, Johan; Dridi, Sami // Cell & Tissue Research;Jun2007, Vol. 329 Issue 1, p91 

    Heat shock protein (HSP)-70 is expressed in normal and stressed cells but is highly stress-inducible. Although leptin has long been suggested to be involved in the regulation of stress response, its interaction with the HSP-70 gene is still unknown, under both unstressed and stressed conditions....

  • Ghrelin.  // Encyclopedic Reference of Molecular Pharmacology;2004, p403 

    A definition of the term "ghrelin" is presented. It refers to a 28 amino acid peptide predominantly produced by the stomach, with substantially lower amounts derived from bowel, pancreas, kidney, placenta, pituitary and hypothalamus. The peptide has a strong growth hormone-releasing activity. It...

  • Thyrotrophin in the pars tuberalis triggers photoperiodic response. Nakao, Nobuhiro; Ono, Hiroko; Yamamura, Takashi; Anraku, Tsubasa; Takagi, Tsuyoshi; Higashi, Kumiko; Yasuo, Shinobu; Katou, Yasuhiro; Kageyama, Saburo; Uno, Yumiko; Kasukawa, Takeya; Iigo, Masayuki; Sharp, Peter J.; Iwasawa, Atsushi; Suzuki, Yutaka; Sugano, Sumio; Niimi, Teruyuki; Mizutani, Makoto; Namikawa, Takao; Ebihara, Shizufumi // Nature;3/20/2008, Vol. 452 Issue 7185, p317 

    Molecular mechanisms regulating animal seasonal breeding in response to changing photoperiod are not well understood. Rapid induction of gene expression of thyroid-hormone-activating enzyme (type 2 deiodinase, DIO2) in the mediobasal hypothalamus (MBH) of the Japanese quail (Coturnix japonica)...

  • Characterisation of gastric ghrelin cells in man and other mammals: studies in adult and fetal tissues. Rindi, Guido; Necchi, Vittorio; Savio, Antonella; Torsello, Antonio; Zoli, Michele; Locatelli, Vittorio; Raimondo, Francesca; Cocchi, Daniela; Solcia, Enrico // Histochemistry & Cell Biology;Jun2002, Vol. 117 Issue 6, p511 

    Ghrelin is a new gastric peptide involved in food intake control and growth hormone release. We aimed to assess its cell localisation in man during adult and fetal life and to clarify present interspecies inconsistencies of gastric endocrine cell types. A specific serum generated against amino...

  • Food cues and ghrelin recruit the same neuronal circuitry. van der Plasse, G; Merkestein, M; Luijendijk, M C M; van der Roest, M; Westenberg, H G M; Mulder, A B; Adan, R A H // International Journal of Obesity;Jul2013, Vol. 37 Issue 7, p1012 

    Background:Cues that are associated with the availability of food are known to trigger food anticipatory activity (FAA). This activity is expressed as increased locomotor activity and enables an animal to prepare for maximal utilization of nutritional resources. Although the exact neural network...

  • Central, but not peripheral application of motilin increases c-Fos expression in hypothalamic nuclei in the rat brain. Mei Wu; Ming Tang; Adriaensen, Dirk; Depoortere, Inge; Peeters, Theo; Timmermans, Jean-Pierre // Histochemistry & Cell Biology;Feb2005, Vol. 123 Issue 2, p139 

    Previous immunocytochemical studies have shown the presence of motilin-immunoreactive neurons in specific brain areas of rats and autoradiographic studies in rabbits demonstrated motilin-binding sites in the central nervous system as well. Therefore, the aim of this study was to determine the...

  • Association between plasma metabolites and gene expression profiles in five porcine endocrine tissues. Bin Yang; Bassols, Anna; Saco, Yolanda; Pérez-Enciso, Miguel // Genetics Selection Evolution;Jul2011, Vol. 43 Issue 7, p1 

    Background: Endocrine tissues play a fundamental role in maintaining homeostasis of plasma metabolites such as non-esterified fatty acids and glucose, the levels of which reflect the energy balance or the health status of animals. However, the relationship between the transcriptome of endocrine...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics