Immune regulation and colitis: suppression of acute inflammation allows the development of chronic inflammatory bowel disease

Eksteen, B.; Walker, L. S. K.; Adams, D. H.
January 2005
Gut;Jan2005, Vol. 54 Issue 1, p4
Academic Journal
The article reports that the success of the gastrointestinal immune system depends on a balance between mounting effective immune responses to pathogenic antigens while suppressing potentially damaging responses against commensal organisms or food antigens. Both the innate and acquired immune system contribute to fighting pathogens. The innate immune system, which includes phagocytes, dendritic cells, and natural killer cells, does not require previous exposure to a pathogen and instead relies on evolutionarily ancient pathways such as Toll-like receptors (TLRs) to recognise molecular patterns associated with harmful pathogens. Different TLRs are able to recognise bacterial products or motifs in viral RNA or DNA.


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