Pentazocine Effects on Gastrointestinal Motor Functions in Man

Danhof, Ivan E.
October 1967
American Journal of Gastroenterology;Oct1967, Vol. 48 Issue 4, p295
Academic Journal
The effects on various gastrointestinal motor functions of varying doses of pentazocine given intramuscularly to human subjects were evaluated. Side-effects including nasal pruritus, auditory hyperacuity, nausea, disequilibrium and muscular weakness were bothersome, but of minimal clinical significance. No significant variations in respiratory frequency or blood pressure from the control were noted, Pentazocine did not interfere significantly with the motor response of the gallbladder to intravenously administered cholecystokinin, although in two of five subjects at the highest dosage level, 40 mg., some spasmogenic activity, probably drug-related, of the sphincter of Oddi was noted as indicated by minimally increased serum amylase levels. In the remaining three subjects given 40 mg. doses and in nine subjects at 30 or 15 mg. doses no such sphincteric spasm was noted. Pentazocine in small doses has a rather marked effect in delaying gastric emptying and in larger doses delays small intestinal propulsive motility, stomach to rectum transit of an oxygen bolus, and depresses rectosigmoid motility. Possible areas of therapeutic usefulness of the observed effects are suggested. Hematograms and urinalyses pre- and postmedication revealed no significant abnormalities.


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